Recent developments in phasing and structure refinement for macromolecular crystallography

被引：21

作者：

Adams, Paul D. ^{[1
,2
]}

Afonine, Pavel V. ^{[1
]}

Grosse-Kunstleve, Ralf W. ^{[1
]}

Read, Randy J. ^{[3
]}

Richardson, Jane S. ^{[4
]}

Richardson, David C. ^{[4
]}

Terwilliger, Thomas C. ^{[5
]}

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Lab, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA

[3] Cambridge Inst Med Res, Cambridge CB2 0XY, England

[4] Duke Univ, Med Ctr, Dept Biochem, Durham, NC 27710 USA

[5] Los Alamos Natl Lab, Los Alamos, NM 87545 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2009年 / 19卷 / 05期

基金：

英国惠康基金;

关键词：

ANISOTROPIC THERMAL PARAMETERS; NORMAL-MODE REFINEMENT; MAXIMUM-LIKELIHOOD; MOLECULAR-REPLACEMENT; X-RAY; DENSITY-MODIFICATION; STRUCTURE VALIDATION; ACCURACY; INFORMATION; DIFFRACTION;

D O I：

10.1016/j.sbi.2009.07.014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Central to crystallographic structure solution is obtaining accurate phases in order to build a molecular model, ultimately followed by refinement of that model to optimize its fit to the experimental diffraction data and prior chemical knowledge. Recent advances in phasing and model refinement and validation algorithms make it possible to arrive at better electron density maps and more accurate models.

引用

页码：566 / 572

页数：7

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