Beyond T Cells: Understanding the Role of PD-1/PD-L1 in Tumor-Associated Macrophages

被引：104

作者：

Lu, Di ^{[1
]}

Ni, Zhen ^{[1
]}

Liu, Xiguang ^{[1
]}

Feng, Siyang ^{[1
]}

Dong, Xiaoying ^{[1
]}

Shi, Xiaoshun ^{[1
]}

Zhai, Jianxue ^{[1
]}

Mai, Shijie ^{[1
]}

Jiang, Jianjun ^{[1
]}

Wang, Zhizhi ^{[1
]}

Wu, Hua ^{[1
]}

Cai, Kaican ^{[1
]}

机构：

[1] Southern Med Univ, Nanfang Hosp, Dept Thorac Surg, Guangzhou 510515, Guangdong, Peoples R China

来源：

JOURNAL OF IMMUNOLOGY RESEARCH | 2019年 / 2019卷

关键词：

UP-REGULATION; PD-1; EXPRESSION; PROMOTE IMMUNOSUPPRESSION; CANCER-IMMUNOTHERAPY; B7-H1; M1; PHENOTYPE; OPEN-LABEL; PEMBROLIZUMAB; M2; POLARIZATION;

D O I：

10.1155/2019/1919082

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Programmed cell death protein 1 (PD-1) and its ligand PD-L1 have attracted wide attention from researchers in the field of immunotherapy. PD-1/PD-L1 have been shown to exist in many types of cells in addition to T lymphocytes, and studies have accordingly extended from their suppressive effect on T cell activation and function to examining their role in other cells. In this review, we summarize recent research on PD-1/PD-L1 in macrophages, with the aim of furthering our understanding of PD-1/PD-L1 and their detailed roles in macrophages. This information may provide additional insights for researchers, enrich the basic theory of anti-PD-1/PD-L1 immunotherapy, and thus ultimately benefit more patients.

引用

页数：7

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