Association between B-Myb proto-oncogene and the development of malignant tumors

被引：10
作者：
Jin, Yuelei [1 ,2 ]
Qi, Gangqiao [2 ]
Chen, Guang [1 ]
Wang, Chen [3 ]
Fan, Xiaoyan [1 ]
机构：
[1] Taizhou Univ, Dept Basic Med Sci, 1139 Shifu Rd, Taizhou 318000, Zhejiang, Peoples R China
[2] Taizhou Second Peoples Hosp, Dept Sleep, Med Ctr, Taizhou 317200, Zhejiang, Peoples R China
[3] Taizhou Univ, Dept Resp Med, Municipal Hosp, Med Sch, Taizhou 318000, Zhejiang, Peoples R China
来源：
ONCOLOGY LETTERS | 2021年 / 21卷 / 02期
关键词：
B-Myb; cancer; mechanisms; CELL-CYCLE REGULATION; HEPATOCELLULAR-CARCINOMA; S-PHASE; MESENCHYMAL TRANSITION; CHROMOSOMAL REGION; PROTEIN EXPRESSION; PROGNOSTIC MARKER; HIGH-GRADE; CANCER; PROLIFERATION;
D O I：
10.3892/ol.2021.12427
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
B-Myb is a critical transcription factor in regulating cell cycle. Dysregulated expression of B-Myb promotes tumor formation and development. B-Myb is a proto-oncogene ubiquitously expressed in proliferating cells, which maintains normal cell cycle progression. It participates in cell apoptosis, tumorigenesis and aging. In addition, B-Myb is overexpressed in several malignant tumors, including breast cancer, lung cancer and hepatocellular carcinoma, and is associated with tumor development. B-Myb expression is also associated with the prognosis of patients with malignant tumors. Both microRNAs and E2F family of transcription factors (E2Fs) contribute to the function of B-Myb. The present review highlights the association between B-Myb and malignant tumors, and offers a theoretical reference for the diagnosis and treatment of malignant tumors.
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页数：8
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