Long intergenic non-coding RNA (lincRNA)-01317 suppresses human gastric cancer growth by inhibiting migration and invasion of cancer cells

被引：2
作者：
Chen, Yong [1 ,3 ]
Zhang, Kundong [2 ]
Yu, Zhilong [2 ]
Wu, Jinsong [3 ]
Qiu, Zhengjun [1 ,2 ]
机构：
[1] Nanjing Med Univ, Dept Gen Surg, Shanghai Gen Hosp, 100 Haining Rd, Shanghai 200080, Peoples R China
[2] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Gen Surg, 100 Haining Rd, Shanghai 200080, Peoples R China
[3] Jiuting Hosp Songjiang Dist, Dept Gen Surg, 155 Jiuxin Rd, Shanghai 201615, Peoples R China
来源：
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH | 2021年 / 13卷 / 02期
关键词：
LincRNA01317; gastric cancer; PROLIFERATION;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Long intergenic noncoding RNAs (lincRNAs) are strongly associated with several kinds of cancer, including gastric cancer. Here, we found significantly decreased lincRNA-01317 levels in cancer tissue compared with paracancer tissue of patients with gastric cancer, and lincRNA-01317 expression levels positively correlated with clinical survival rate. Furthermore, using a gastric cancer cell line and a xenograft mouse model, we found that transfection of a gastric cancer cell line with lincRNA-01317 significantly inhibited the proliferation, migration, and invasion of gastric cancer cells. Finally, we demonstrated that lincRNA-01317 may target KCNQ1, as KCNQ1 was downregulated after transfection of cells with lincRNA-01317. This study aimed to assess lincRNA-01317 as a potential therapeutic target to treat cancers.
引用
收藏
页码：770 / 780
页数：11
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