Cognitive Function in Prepubertal Children with Obstructive Sleep Apnea: A Modifying Role for NADPH Oxidase p22 Subunit Gene Polymorphisms?

被引：52

作者：

Gozal, David ^{[1
]}

Khalyfa, Abdelnaby ^{[1
]}

Sans Capdevila, Oscar ^{[2
]}

Kheirandish-Gozal, Leila ^{[1
]}

Khalyfa, Ahamed A. ^{[1
]}

Kim, Jinkwan ^{[1
]}

机构：

[1] Univ Chicago, Dept Pediat, Pritzker Sch Med, Sect Pediat Sleep Med, Chicago, IL 60637 USA

[2] Hosp San Joan de Deu, Div Child Neurol, Sleep Lab, Barcelona, Spain

来源：

ANTIOXIDANTS & REDOX SIGNALING | 2012年 / 16卷 / 02期

基金：

美国国家卫生研究院;

关键词：

DYSFUNCTION; STRESS;

D O I：

10.1089/ars.2011.4189

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pediatric obstructive sleep apnea (OSA) may lead to neurocognitive dysfunction, but not in everyone affected. The frequencies of NADPH oxidase (NOX) polymorphisms in the p22phox subunit were similar between children with OSA and controls, except for rs6520785 and rs4673, the latter being significantly more frequent among the OSA children without deficits than with deficits (p <0.02). Similarly, 8-hydroxydeoxyguanine urine levels and NOX activity were lower among children without cognitive deficits and particularly among those with the rs4673 polymorphism. Thus, polymorphisms within the NOX gene or its functional subunits may account for important components of the variance in cognitive function deficits associated with OSA in children. Antioxid. Redox Signal. 16, 171-177.

引用

页码：171 / 177

页数：7

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