Light mask 500 lux treatment for delayed sleep phase syndrome

被引:11
作者
Ando, K
Kripke, DF
Cole, RJ
Elliott, JA
机构
[1] Univ Calif San Diego, Dept Psychiat, San Diego, CA 92103 USA
[2] Synchrony Appl Hlth Sci, San Diego, CA USA
关键词
circadian; delayed sleep phase syndrome; light; 6-sulfatoxymelatonin; sleep disorder; temperature;
D O I
10.1016/S0278-5846(98)00088-8
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
1. Bright light exposure has been demonstrated as an effective treatment for circadian rhythm sleep disorders. Recent studies suggest that more moderate intensities of light might affect endogenous rhythms. A light mask treatment, using light applied through eyelids during sleep, was tested for Delayed Sleep Phase Syndrome. 2. The active light group (n=5) received <(500 lux)under bar> light for 3 hours prior to awakening for 12 days. The placebo light group (n=5) received <(0.1 lux)under bar> light with the same timing. Circadian rhythm phase was assessed from core body temperature and urinary 6-sulfatoxymelatonin measurements. The SIGH-SAD-SR mood scale was administered to assess mood. 3. There were slight trends toward a phase advance of the body temperature rhythm and a phase delay of the melatonin rhythm, and both groups reported anti-depressant benefits. However, no statistically significant effects of 500 lux light mask treatment were demonstrated compared with the placebo-light treatment. 4. More extensive studies will be required to clarify the factors of dose-response and phase-response.
引用
收藏
页码:15 / 24
页数:10
相关论文
共 20 条
[1]  
ALDOUS ME, 1988, ANN CLIN BIOCHEM, V25, P298
[2]   Light attenuation by the human eyelid [J].
Ando, K ;
Kripke, DF .
BIOLOGICAL PSYCHIATRY, 1996, 39 (01) :22-25
[3]  
*ASDA DIAGN CLASS, 1990, INT CLASS SLEEP DIS, P1
[4]  
AVERY DH, 1992, J CLIN PSYCHIAT, V53, P359
[5]  
AVERY DH, 1993, AM J PSYCHIAT, V150, P113
[6]   DAWN SIMULATION COMPARED WITH A DIM RED SIGNAL IN THE TREATMENT OF WINTER DEPRESSION [J].
AVERY, DH ;
BOLTE, MAP ;
WOLFSON, JK ;
KAZARAS, AL .
BIOLOGICAL PSYCHIATRY, 1994, 36 (03) :181-188
[7]   SUPPRESSION OF NOCTURNAL PLASMA MELATONIN AND 6-SULFATOXYMELATONIN BY BRIGHT AND DIM LIGHT IN MAN [J].
BOJKOWSKI, CJ ;
ALDHOUS, ME ;
ENGLISH, J ;
FRANEY, C ;
POULTON, AL ;
SKENE, DJ ;
ARENDT, J .
HORMONE AND METABOLIC RESEARCH, 1987, 19 (09) :437-440
[8]   DOSE-RESPONSE RELATIONSHIP BETWEEN LIGHT IRRADIANCE AND THE SUPPRESSION OF PLASMA MELATONIN IN HUMAN VOLUNTEERS [J].
BRAINARD, GC ;
LEWY, AJ ;
MENAKER, M ;
FREDRICKSON, RH ;
MILLER, LS ;
WELEBER, RG ;
CASSONE, V ;
HUDSON, D .
BRAIN RESEARCH, 1988, 454 (1-2) :212-218
[9]  
COLE RJ, 1991, SLEEP RES, V20, P450
[10]  
Cole SA, 1996, J NEUROPSYCH CLIN N, V8, P20