Towards the prevention of potential aluminum toxic effects and an effective treatment for Alzheimer's disease

被引：75

作者：

Percy, Maire E. ^{[1
,2
,3
]}

Kruck, Theo P. A. ^{[1
]}

Pogue, Aileen I. ^{[4
]}

Lukiw, Walter J. ^{[5
,6
]}

机构：

[1] Surrey Pl Ctr, Neurogenet Lab, Toronto, ON M5S 2C2, Canada

[2] Univ Toronto, Dept Physiol, Toronto, ON M5S 1A8, Canada

[3] Univ Toronto, Dept Obstet & Gynaecol, Toronto, ON M5S 1A8, Canada

[4] Alchem Biotek Corp, Toronto, ON M5T 1LP, Canada

[5] Louisiana State Univ, Hlth Sci Ctr, Dept Genet, Ctr Neurosci, New Orleans, LA 70112 USA

[6] Louisiana State Univ, Hlth Sci Ctr, Dept Ophthalmol, Ctr Neurosci, New Orleans, LA 70112 USA

来源：

JOURNAL OF INORGANIC BIOCHEMISTRY | 2011年 / 105卷 / 11期

关键词：

Aluminum toxicity; Alzheimer's disease; Antioxidants; Chelators; Inflammation; Oxidative stress; AMYLOID PRECURSOR PROTEIN; MILD COGNITIVE IMPAIRMENT; NF-KAPPA-B; OXIDATIVE STRESS; BRAIN ALUMINUM; BETA-PROTEIN; DIFFERENTIAL REGULATION; CHLAMYDIA-PNEUMONIAE; MULTIPLE-SCLEROSIS; APOLIPOPROTEIN-E;

D O I：

10.1016/j.jinorgbio.2011.08.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In 1991, treatment with low dose intramuscular desferrioxamine (DFO), a trivalent chelator that can remove excessive iron and/or aluminum from the body, was reported to slow the progression of Alzheimer's disease (AD) by a factor of two. Twenty years later this promising trial has not been followed up and why this treatment worked still is not clear. In this critical interdisciplinary review, we provide an overview of the complexities of AD and involvement of metal ions, and revisit the neglected DFO trial. We discuss research done by us and others that is helping to explain involvement of metal ion catalyzed production of reactive oxygen species in the pathogenesis of AD, and emerging strategies for inhibition of metal-ion toxicity. Highlighted are insights to be considered in the quests to prevent potentially toxic effects of aluminum toxicity and prevention and intervention in AD. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：1505 / 1512

页数：8

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