Caffeic Acid, A Versatile Pharmacophore: An Overview

被引：153
作者：
Touaibia, M. [1 ]
Jean-Francois, J. [1 ]
Doiron, J. [1 ]
机构：
[1] Univ Moncton, Dept Chem & Biochem, Moncton, NB E1A 3E9, Canada
来源：
MINI-REVIEWS IN MEDICINAL CHEMISTRY | 2011年 / 11卷 / 08期
关键词：
Caffeic acid; anticancer; antioxidant; anti-inflammatory; integrase inhibitors; structure-activity relationships; IMMUNODEFICIENCY-VIRUS TYPE-1; PHENETHYL ESTER CAPE; RADICAL SCAVENGING ACTIVITY; NITRIC-OXIDE; HIV-1; INTEGRASE; ANTIPROLIFERATIVE ACTIVITY; PREFERENTIAL CYTOTOXICITY; DICAFFEOYLTARTARIC ACIDS; ANTIOXIDATIVE ACTIVITIES; ANTICANCER PROPERTIES;
D O I：
10.2174/138955711796268750
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The caffeic acid scaffold, which is abundant in nature, is extremely versatile and is found in a number of biologically active molecules. The purpose of this review is to provide an overview of the pharmacological activity of synthetic caffeic acid analogs including recent reports of anti-inflammatory, anti-cancer, and antiviral activities of these compounds.
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页码：695 / 713
页数：19
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