Predominance of Th2 response in human abdominal aortic aneurysm: Mistaken identity for IL-4-producing NK and NKT cells?

被引:33
作者
Chan, WL
Pejnovic, N
Liew, TV
Hamilton, H
机构
[1] Queen Mary Univ London, John Vane Sci Ctr, William Harvey Res Inst, London EC1M 6BQ, England
[2] Barnet & Chase Farm Hosp NHS Trust, Gen Surg, Enfield, Middx, England
基金
英国惠康基金;
关键词
NKT; NK cells; abdominal aortic aneurysm;
D O I
10.1016/j.cellimm.2005.04.020
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Abdominal aortic aneurysm (AAA) is a complex remodeling process that involves both synthesis and degradation of extracellular matrix proteins in the aortic wall, leading to decreased tensile strength, progressive dilation and eventual rupture. Chronic inflammation, increased local production of elastin-degrading proteases by inflammatory cells and destruction of medial elastic lamellae play important roles in aneurysm progression. Neovascularization in all layers of the arterial wall is prominent and angiogenesis can facilitate chronic inflammation. It is still unclear what initiates aneurysmal dilation and what determines its progression. The complex nature of the process has defied elucidation. Apart from macrophages, the predominant immune cell infiltrates reported so far are CD3(+)T cells that express CD4 and CD8. Infiltrates of type 2 Th cells and their production of IL-4 and IL-5 have been implicated in AAA development. However, NKT and NK cells have a Th0 cytokine profile and can also produce type 2 as well as type I (IL-2 and IFN gamma) cytokines. We have demonstrated the presence of NK and NKT cells in AAA tissue. With their growing importance in autoimmunity and transplantation, they may play a role in AAA development. Therefore, there is a need to use a combination of T and NK markers to fully characterize both innate and adaptive lymphoid cell subsets in local inflammatory infiltrates in order to elucidate their roles in AAA progression. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码:109 / 114
页数:6
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