Synthesis of functionalized unsymmetrical 1,3-butadiene-3-yne derivatives from β-halo styrene derivatives and their application in the synthesis of trisubstituted pyridines

被引：5

作者：

Bandi, Vijayalakshmi ^{[1
]}

Kavala, Veerababurao ^{[1
]}

Hsu, Che-Hao ^{[1
]}

Konala, Ashok ^{[1
]}

Villuri, Bharath Kumar ^{[1
]}

Kotipalli, Trimurtulu ^{[1
]}

Kuo, Chun-Wei ^{[1
]}

Yao, Ching-Fa ^{[1
]}

机构：

[1] Natl Taiwan Normal Univ, Dept Chem, 88,Sect 4,Tingchow Rd, Taipei 116, Taiwan

来源：

RSC ADVANCES | 2017年 / 7卷 / 74期

关键词：

TERMINAL ALKYNES; 2,4,6-TRISUBSTITUTED PYRIDINES; CROSS-TRIMERIZATION; DIMERIZATION; OLIGOMERIZATION; COMPLEXES;

D O I：

10.1039/c7ra07128k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An approach for the synthesis of functionalized unsymmetrical 1,3-butadiene-3-yne derivatives is reported starting from beta-halo styrene and phenyl acetylene derivatives in the presence of PdCl2 and CuI catalysts. Functional groups such as aldehyde, cyano and ester groups are well tolerated and afford the desired functionalized dienynes. Further, these 1,3-buta-diene-3-yne derivatives are utilized for the synthesis of novel trisubstituted pyridine derivatives.

引用

页码：46704 / 46712

页数：9

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