Sigma-1 Receptor-Modulated Neuroinflammation in Neurological Diseases

被引：75

作者：

Jia, Jia ^{[1
,2
]}

Cheng, Jian ^{[3
]}

Wang, Cheng ^{[4
]}

Zhen, Xuechu ^{[1
,2
]}

机构：

[1] Soochow Univ, Jiangsu Key Lab Neuropsychiat Dis, Suzhou, Peoples R China

[2] Soochow Univ, Coll Pharmaceut Sci, Suzhou, Peoples R China

[3] Soochow Univ, Inst Neurosci, Suzhou, Peoples R China

[4] Suzhou Sci & Technol Town Hosp, Dept Pharm, Suzhou, Peoples R China

来源：

FRONTIERS IN CELLULAR NEUROSCIENCE | 2018年 / 12卷

基金：

美国国家科学基金会;

关键词：

sigma-1; receptor; neuroinflammation; neurological diseases; microglia; astrocytes; AMYOTROPHIC-LATERAL-SCLEROSIS; CENTRAL-NERVOUS-SYSTEM; ACUTE ISCHEMIC-STROKE; PARKINSONS-DISEASE; ALZHEIMERS-DISEASE; BINDING-SITES; MOUSE MODEL; NEURODEGENERATIVE DISEASES; MICROGLIAL ACTIVATION; ALLOSTERIC MODULATION;

D O I：

10.3389/fncel.2018.00314

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A large body of evidence indicates that sigma-1 receptors (Sig-1R) are important drug targets for a number of neuropsychiatric disorders. Sig-1Rs are enriched in central nervous system (CNS). In addition to neurons, both cerebral microglia and astrocytes express Sig-1Rs. Activation of Sig-1Rs is known to elicit potent neuroprotective effects and promote neuronal survival via multiple mechanisms, including promoting mitochondrial functions, decreasing oxidative stress and regulating neuroimmnological functions. In this review article, we focus on the emerging role of Sig-1Rs in regulating neuroinflammation and discuss the recent advances on the Sig-1R-modulating neuroinflammation in the pathophysiology and therapy of neurodegenerative disorders.

引用

页数：7

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