Malignant Transformation in Mature Cystic Teratomas of the Ovary: Case Reports and Review of the Literature

被引：17
作者：
Gadducci, Angiolo [1 ]
Pistolesi, Sabina [2 ]
Guerrieri, Maria Elena [1 ]
Cosio, Stefania [1 ]
Carbone, Francesco Giuseppe [2 ]
Naccarato, Antonio Giuseppe [2 ]
机构：
[1] Univ Pisa, Div Gynecol & Obstet, Dept Expt & Clin Med, Via Roma 56, I-56127 Pisa, Italy
[2] Univ Pisa, Div Pathol, Dept New Technol & Translat Res, Pisa, Italy
来源：
ANTICANCER RESEARCH | 2018年 / 38卷 / 06期
关键词：
Teratoma of the ovary; squamous cell carcinoma; papillary renal cell cancer; thyroid carcinoma; struma ovarii; surgery; SQUAMOUS-CELL CARCINOMA; STRUMA OVARII; HUMAN-PAPILLOMAVIRUS; SURVIVAL; BENIGN; CANCER; SERIES; FOCUS;
D O I：
10.21873/anticanres.12644
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Malignant transformation occurs in 1.5-2% of mature cystic teratomas (MCT)s of the ovary and usually consists of squamous cell carcinoma, whereas other malignancies are less common. Diagnosis and treatment represent a challenge for gynecologic oncologists. The preoperative detection is very difficult and the diagnostic accuracy of imaging examinations is uncertain. The tumor is usually detected post-operatively based on histopathologic findings. This paper reviewed 206 consecutive patients who underwent surgery for a histologically-proven MCT of the ovary between 2010 and 2017. Malignant transformation occurred in 3 (1.5%) of them, and consisted of squamous cell carcinoma in one, type 2 papillary renal carcinoma in one, and papillary thyroid carcinoma in another one. The paper reported the clinical, radiological and histological features of these cases and reviewed the literature data on the treatment options.
引用
收藏
页码：3669 / 3675
页数：7
相关论文
共 46 条
[1]   A review of squamous cell carcinoma arising in mature cystic teratoma of the ovary [J].
Abhilasha, N. ;
Bafna, U. D. ;
Pallavi, V. R. ;
Rathod, P. S. ;
Krishnappa, S. .
INDIAN JOURNAL OF CANCER, 2016, 53 (04) :612-614
[2]  
Araujo IB, 2000, INT J GYNECOL PATHOL, V35, P176
[3]   Preoperative diagnosis of mature cystic teratoma with malignant transformation: Analysis of imaging findings and clinical and laboratory data [J].
Park S.B. ;
Kim J.K. ;
Kim K.-R. ;
Cho K.-S. .
Archives of Gynecology and Obstetrics, 2007, 275 (1) :25-31
[4]   A Series of Malignant Ovarian Cancers Arising From Within a Mature Cystic Teratoma A Single Institution Experience [J].
Black, Jonathan D. ;
Roque, Dana M. ;
Pasternak, Monica C. ;
Buza, Natalia ;
Rutherford, Thomas J. ;
Schwartz, Peter E. ;
McCarthy, Shirley ;
Ratner, Elena .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2015, 25 (05) :792-797
[5]   Prognosis and Treatment of Squamous Cell Carcinoma from a Mature Cystic Teratoma of the Ovary [J].
Chen, Ruey-Jien ;
Chen, Ko-Yang ;
Chang, Ting-Chen ;
Sheu, Bor-Ching ;
Chow, Song-Nan ;
Huang, Su-Cheng .
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 2008, 107 (11) :857-868
[6]   Detection of human papillomavirus in squamous cell carcinoma arising from dermoid cysts [J].
Chiang, An-Jen ;
Chen, Di-Rong ;
Cheng, Jiin-Tsuey ;
Chang, Tsung-Hsien .
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY, 2015, 54 (05) :559-566
[7]   Squamous Cell Carcinoma Arising From Mature Cystic Teratoma of the Ovary [J].
Chiang, An-Jen ;
La, Victor ;
Peng, Jiaqi ;
Yu, Ken-Jen ;
Teng, Nelson N. H. .
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER, 2011, 21 (03) :466-474
[8]   Papillary renal cell carcinoma: A review of the current therapeutic landscape [J].
Courthod, Giulia ;
Tucci, Marcello ;
Di Maio, Massimo ;
Scagliotti, Giorgio V. .
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2015, 96 (01) :100-112
[9]   Malignant struma ovarii: Two case reports and a review of the literature [J].
Dardik, RB ;
Dardik, M ;
Westra, W ;
Montz, FJ .
GYNECOLOGIC ONCOLOGY, 1999, 73 (03) :447-451
[10]   Morphologic typing of papillary renal cell carcinoma: Comparison of growth kinetics and patient survival in 66 cases [J].
Delahunt, B ;
Eble, JN ;
McCredie, MRE ;
Bethwaite, PB ;
Stewart, JH ;
Bilous, AM .
HUMAN PATHOLOGY, 2001, 32 (06) :590-595
12345