Decreased serum betatrophin may correlate with the improvement of obstructive sleep apnea after Roux-en-Y Gastric Bypass surgery

被引：1

作者：

Song, Zhiyuan ^{[1
,2
,3
]}

Guo, Kaifeng ^{[4
,5
,6
,7
]}

Huang, Weijun ^{[1
,2
,3
]}

Xu, Huajun ^{[1
,2
,3
]}

Liu, Yupu ^{[1
,2
,3
]}

Guan, Jian ^{[1
,2
,3
]}

Yin, Shankai ^{[1
,2
,3
]}

Yu, Haoyong ^{[4
]}

Yi, Hongliang ^{[1
,2
,3
]}

Zou, Jianyin ^{[1
,2
,3
]}

机构：

[1] Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Dept Otolaryngol Head & Neck Surg, 600 Yishan Rd, Shanghai 200233, Peoples R China

[2] Shanghai Key Lab Sleep Disordered Breathing, Shanghai 200233, Peoples R China

[3] Shanghai Jiao Tong Univ, Otolaryngol Inst, Shanghai 200233, Peoples R China

[4] Shanghai Jiao Tong Univ, Peoples Hosp 6,Shanghai Clin Ctr Diabet, Shanghai Key Clin Ctr Metab Dis,Shangai Diabet In, Dept Endocrinol & Metab,Shanghai Key Lab Diabet M, 600 Yishan Rd, Shanghai 200233, Peoples R China

[5] Fudan Univ, Minhang Hosp, Dept Endocrinol & Metab, Shanghai 201199, Peoples R China

[6] Fudan Univ, Zhongshan Hosp, Minhang Branch, Shanghai 201199, Peoples R China

[7] Cent Hosp Minhang Dist, Shanghai 201199, Peoples R China

来源：

SCIENTIFIC REPORTS | 2021年 / 11卷 / 01期

基金：

中国国家自然科学基金;

关键词：

BARIATRIC SURGERY; WEIGHT-LOSS; OBESITY; ASSOCIATIONS; INFLAMMATION; POPULATION; IMPACT; FAT;

D O I：

10.1038/s41598-021-81379-1

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Obesity is strongly correlated with obstructive sleep apnea (OSA), and bariatric surgery can effectively treat obesity and alleviate OSA. However, the contributing factors are still unclear. We aimed to explore the relationship between betatrophin and OSA in patients undergoing Roux-en-Y gastric bypass (RYGB) surgery. Our study consisted of thirty-seven individuals with OSA and type 2 diabetes (16 males, 21 females) undergoing RYGB surgery. The polysomnography test, anthropometric results, serum betatrophin, and abdominal magnetic resonance images were evaluated both before and 1 year after RYGB surgery. Factors that may correlate with the alleviation of OSA were investigated. In our study, RYGB surgery significantly decreased apnea hypopnea index (AHI) and serum betatrophin concentration (p<0.001). The abdominal visceral fat area, subcutaneous fat area and HOMA-IR were also significantly decreased (p<0.001). The preoperative AHI, postoperative AHI and the change in AHI were significantly correlated with the preoperative betatrophin, postoperative betatrophin and the change in betatrophin, respectively (p<0.05). These correlations were still significant after adjustment for other risk factors. The change in betatrophin was also independently associated with the change in minimum oxygen saturation (p<0.001). Our data might indicate that serum betatrophin was significantly independently correlated with the improvement of OSA after bariatric surgery.

引用

页数：7

共 34 条

[31] Obesity and obstructive sleep apnea - Clinical significance of weight loss [J].