Metformin: review of epidemiology and mechanisms of action in pancreatic cancer

被引：38

作者：

Eibl, Guido ^{[1
]}

Rozengurt, Enrique ^{[2
]}

机构：

[1] UCLA, David Geffen Sch Med, Dept Surg, Los Angeles, CA 90095 USA

[2] UCLA, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USA

来源：

CANCER AND METASTASIS REVIEWS | 2021年 / 40卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Metformin; Pancreatic cancer; Epidemiology; Preclinical studies; Mechanisms; YES-ASSOCIATED PROTEIN; ANTIDIABETIC DRUG METFORMIN; AMPK-MEDIATED REGULATION; BODY-MASS INDEX; DUCTAL ADENOCARCINOMA; IN-VITRO; ONCOGENIC KRAS; CELL-PROLIFERATION; DIABETIC-PATIENTS; COUPLED RECEPTOR;

D O I：

10.1007/s10555-021-09977-z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Pancreatic ductal adenocarcinoma continues to be a lethal disease, for which efficient treatment options are very limited. Increasing efforts have been taken to understand how to prevent or intercept this disease at an early stage. There is convincing evidence from epidemiologic and preclinical studies that the antidiabetic drug metformin possesses beneficial effects in pancreatic cancer, including reducing the risk of developing the disease and improving survival in patients with early-stage disease. This review will summarize the current literature about the epidemiological data on metformin and pancreatic cancer as well as describe the preclinical evidence illustrating the anticancer effects of metformin in pancreatic cancer. Underlying mechanisms and targets of metformin will also be discussed. These include direct effects on transformed pancreatic epithelial cells and indirect, systemic effects on extra-pancreatic tissues.

引用

页码：865 / 878

页数：14

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