The Study of Nerve Conduit with Biocompatibility and Electrical Stimulation Effect

被引：4

作者：

Guo Xinglei ^{[1
]}

Liu Gang ^{[2
]}

He Qundi ^{[3
]}

Xu Haixing ^{[1
]}

Yu Yunxuan ^{[1
]}

Ke Changsheng ^{[1
]}

Ming Xiaofei ^{[1
]}

Zhao Meng ^{[1
]}

Wang Xiaobin ^{[4
]}

Huang Zhijun ^{[1
]}

Xu Peihu ^{[1
]}

机构：

[1] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Dept Pharmaceut Engn, Wuhan 430070, Hubei, Peoples R China

[2] Wuhan Univ, Dept Pharm, Renmin Hosp, Wuhan 430060, Hubei, Peoples R China

[3] Wuhan Mafangshan Middle Sch, Wuhan 430070, Hubei, Peoples R China

[4] Wuhan Kanghua Century Pharmaceut Co, Wuhan 430070, Hubei, Peoples R China

来源：

JOURNAL OF WUHAN UNIVERSITY OF TECHNOLOGY-MATERIALS SCIENCE EDITION | 2018年 / 33卷 / 06期

基金：

中国国家自然科学基金;

关键词：

nerve injury; polymer; poly-dl-lactic-acid; tetra-aniline; conduit; CONDUCTIVE POLYMERS; GROWTH-FACTOR; TISSUE; POLYPYRROLE; COMPOSITE; REGENERATION; DEGRADATION; FABRICATION; NANOFIBERS; SCAFFOLDS;

D O I：

10.1007/s11595-018-2002-x

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Conductive polymers show great promise because of their electrical property based on bioelectricity in vivo. In order to search electro-activity materials which insure abduction of tissue, we synthesized conductive nerve conduits with poly-dl-lactic-acid (PDLLA) and tetra-aniline (TA). Preparation technology of TA was optimized, and the properties of the conduit were studied. RSC96 cell were used to investigate the toxicity and electrical stimulation effect. SD rats were used to assess biocompatibility in vivo. The results showed that the reaction ratio of 1:1, the reaction time of 2 h and the HCl concentration of 2 mol/L were the optimum conditions for synthesis of TA. The influence of TA content on the mechanical properties, hydrophilicity, conductivity and microstructure of the nerve conduit was evaluated. Cell and histocompatibility study showed PDLLA/TA possessed good biocompatibility. These results showed it had application values in tissue projects.

引用

页码：1530 / 1539

页数：10

共 35 条

[11] Application of conductive polymers, scaffolds and electrical stimulation for nerve tissue engineering [J].

Ghasemi-Mobarakeh, Laleh ;

Prabhakaran, Molamma P. ;

Morshed, Mohammad ;

Nasr-Esfahani, Mohammad Hossein ;

Baharvand, Hossein ;

Kiani, Sahar ;

Al-Deyab, SalemS ;

Ramakrishna, Seeram .

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE, 2011, 5 (04) :E17-E35

[12] Thermal degradation study of PVA derivative with pendant phenylthionecarbamate groups by DSC/TGA and GC/MS [J].

Gomez, I. ;

Otazo, E. M. ;

Hernandez, H. ;

Rubio, E. ;

Varela, J. ;

Ramirez, M. ;

Barajas, I. ;

Gordillo, A. J. .

POLYMER DEGRADATION AND STABILITY, 2015, 112 :132-136

[13] Nerve growth factor-immobilized polypyrrole: Bioactive electrically conducting polymer for enhanced neurite extension [J].

Gomez, Natalia ;

Schmidt, Christine E. .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2007, 81A (01) :135-149

[14] Conducting polymer-hydrogels for medical electrode applications [J].

Green, Rylie A. ;

Baek, Sungchul ;

Poole-Warren, Laura A. ;

Martens, Penny J. .

SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS, 2010, 11 (01)

[15] Biocompatibility and degradation characteristics of PLGA-based electrospun nanofibrous scaffolds with nanoapatite incorporation [J].

Ji, Wei ;

Yang, Fang ;

Seyednejad, Hajar ;

Chen, Zhi ;

Hennink, Wim E. ;

Anderson, James M. ;

van den Beucken, Jeroen J. J. P. ;

Jansen, John A. .

BIOMATERIALS, 2012, 33 (28) :6604-6614

[16] Effect of immobilized nerve growth factor on conductive polymers: Electrical properties and cellular response [J].

Kim, Dong-Hwan ;

Richardson-Burns, Sarah M. ;

Hendricks, Jeffrey L. ;

Sequera, Cynthia ;

Martin, David C. .

ADVANCED FUNCTIONAL MATERIALS, 2007, 17 (01) :79-86

[17] Synthesis and spectroscopic properties of aniline tetramers.: Comparative studies [J].

Kulszewicz-Bajer, I ;

Rózalska, I ;

Kurylek, M .

NEW JOURNAL OF CHEMISTRY, 2004, 28 (06) :669-675

[18] Polypyrrole-coated electrospun PLGA nanofibers for neural tissue applications [J].

Lee, Jae Y. ;

Bashur, Chris A. ;

Goldstein, Aaron S. ;

Schmidt, Christine E. .

BIOMATERIALS, 2009, 30 (26) :4325-4335

[19] Electrospinning polyaniline-contained gelatin nanofibers for tissue engineering applications [J].

Li, MY ;

Guo, Y ;

Wei, Y ;

MacDiarmid, AG ;

Lelkes, PI .

BIOMATERIALS, 2006, 27 (13) :2705-2715

[20] Peripheral nerve regeneration using composite poly(lactic acid-caprolactone)/nerve growth factor conduits prepared by coaxial electrospinning [J].

Liu, Jun-Jian ;

Wang, Chun-Yang ;

Wang, Jian-Guang ;

Ruan, Hong-Jiang ;

Fan, Cun-Yi .

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, 2011, 96A (01) :13-20

← 1 2 3 4 →