An efficient synthesis of an optically active (-)-(3R, 4R, 5R)-4-(1-hydroxylisopropyl)-3-acetyloxyl-butyrolactone

被引：0

作者：

Wang, JX

Zhang, CX

Li, Y ^{[1
]}

You, QD

机构：

[1] China Pharmaceut Univ, Dept Med Chem, Nanjing 210009, Peoples R China

[2] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH-S | 2005年 / 10期

关键词：

asymmetric synthesis; optically active beta-hydroxy butyrolactones; tuxpanolide; sharpless asymmetric dihydroxylation; X-ray crystal structure;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An optically active beta-hydroxyl-gamma-butyrolactone was synthesised from nonchiral starting material by employing reductive cleavage reaction, Sharpless asymmetric epoxidation and dihydroxylation as key steps. This strategy can be used to prepare many chiral beta-hydroxyl-gamma-butyrolactone analogues. The crystal structure of 10 was determined by X-ray crystallographs.

引用

页码：665 / 668

页数：4

共 22 条

[1] ALLERGENIC ALPHA-METHYLENE-GAMMA-BUTYROLACTONES - BETA-HYDROXY-ALPHA-METHYLENE-GAMMA-BUTYROLACTONES .2. SYNTHESES FROM ETHYL 2-(PHENYLTHIO)PROPIONATE AND ALPHA-ACETOXY ALDEHYDES [J].