Insights into Biological Complexity from Simple Foundations

被引：3

作者：

Albergante, L. ^{[1
]}

Liu, D. ^{[1
]}

Palmer, S. ^{[1
]}

Newman, T. J. ^{[1
]}

机构：

[1] Univ Dundee, Sch Life Sci, Dundee DD1 5EH, Scotland

来源：

BIOPHYSICS OF INFECTION | 2016年 / 915卷

关键词：

Simplicity; Theoretical physics; Probability theory; Gene regulatory networks; DNA replication; Big data; REPLICATION ORIGINS;

D O I：

10.1007/978-3-319-32189-9_18

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We discuss an overtly "simple approach" to complex biological systems borrowing selectively from theoretical physics. The approach is framed by three maxims, and we show examples of its success in two different applications: investigating cellular robustness at the level of gene regulatory networks and quantifying rare events of DNA replication errors.

引用

页码：295 / 305

页数：11

共 20 条

[1] Buffered Qualitative Stability explains the robustness and evolvability of transcriptional networks [J].

Albergante, Luca ;

Blow, J. Julian ;

Newman, Timothy J. .

ELIFE, 2014, 3 :e02863

[2]

Alon U, 2007, INTRO SYSTEMS BIOL D

[3]

[Anonymous], 2010, Networks: An Introduction, DOI 10.1162/artl_r_00062

[4]

Auton A., 2015, Nature, V526, P68, DOI [DOI 10.1038/NATURE15393, 10.1038/nature15393]

[5] Preventing re-replication of chromosomal DNA [J].

Blow, JJ ;

Dutta, A .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2005, 6 (06) :476-486

[6] Quantifying metastatic inefficiency: rare genotypes versus rare dynamics [J].

Cisneros, Luis H. ;

Newman, Timothy J. .

PHYSICAL BIOLOGY, 2014, 11 (04)

[7] Architecture of the human regulatory network derived from ENCODE data [J].

Gerstein, Mark B. ;

Kundaje, Anshul ;

Hariharan, Manoj ;

Landt, Stephen G. ;

Yan, Koon-Kiu ;

Cheng, Chao ;

Mu, Xinmeng Jasmine ;

Khurana, Ekta ;

Rozowsky, Joel ;

Alexander, Roger ;

Min, Renqiang ;

Alves, Pedro ;

Abyzov, Alexej ;

Addleman, Nick ;

Bhardwaj, Nitin ;

Boyle, Alan P. ;

Cayting, Philip ;

Charos, Alexandra ;

Chen, David Z. ;

Cheng, Yong ;

Clarke, Declan ;

Eastman, Catharine ;

Euskirchen, Ghia ;

Frietze, Seth ;

Fu, Yao ;

Gertz, Jason ;

Grubert, Fabian ;

Harmanci, Arif ;

Jain, Preti ;

Kasowski, Maya ;

Lacroute, Phil ;

Leng, Jing ;

Lian, Jin ;

Monahan, Hannah ;

O'Geen, Henriette ;

Ouyang, Zhengqing ;

Partridge, E. Christopher ;

Patacsil, Dorrelyn ;

Pauli, Florencia ;

Raha, Debasish ;

Ramirez, Lucia ;

Reddy, Timothy E. ;

Reed, Brian ;

Shi, Minyi ;

Slifer, Teri ;

Wang, Jing ;

Wu, Linfeng ;

Yang, Xinqiong ;

Yip, Kevin Y. ;

Zilberman-Schapira, Gili .

NATURE, 2012, 489 (7414) :91-100

[8] The emergence of geometric order in proliferating metazoan epithelia [J].

Gibson, Matthew C. ;

Patel, Ankit B. ;

Nagpal, Radhika ;

Perrimon, Norbert .

NATURE, 2006, 442 (7106) :1038-1041

[9] Transcriptional regulatory code of a eukaryotic genome [J].

Harbison, CT ;

Gordon, DB ;

Lee, TI ;

Rinaldi, NJ ;

Macisaac, KD ;

Danford, TW ;

Hannett, NM ;

Tagne, JB ;

Reynolds, DB ;

Yoo, J ;

Jennings, EG ;

Zeitlinger, J ;

Pokholok, DK ;

Kellis, M ;

Rolfe, PA ;

Takusagawa, KT ;

Lander, ES ;

Gifford, DK ;

Fraenkel, E ;

Young, RA .

NATURE, 2004, 431 (7004) :99-104

[10]

Hollis Mark, 1998, DANISH NATL TEL 0222

← 1 2 →