Radical Metal-Free Borylation of Aryl Iodides

被引：27

作者：

Pinet, Sandra ^{[1
]}

Liautard, Virginie ^{[1
]}

Debiais, Megane ^{[1
]}

Pucheault, Mathieu ^{[1
]}

机构：

[1] Univ Bordeaux, Inst Sci Mol, Bordeaux INP, UMR CNRS 5255, 351 Cours Liberat, F-33405 Talence, France

来源：

SYNTHESIS-STUTTGART | 2017年 / 49卷 / 21期

关键词：

metal-free borylation; radical process; cesium fluoride; pyridine; PALLADIUM-CATALYZED BORYLATION; ARYLBORONIC PINACOL ESTERS; POTASSIUM TERT-BUTOXIDE; AMINE-BORANE COMPLEXES; ROOM-TEMPERATURE; AROMATIC-AMINES; MILD CONDITIONS; BOND FORMATION; BORINIC ACIDS; BORON SOURCE;

D O I：

10.1055/s-0036-1588431

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple metal-free borylation of aryl iodides mediated by a fluoride sp(2)-sp(3) diboron adduct is described. The reaction conditions are compatible with various functional groups. Electronic effects of substituents do not affect the borylation while steric hindrance does. The reaction proceeds via a radical mechanism in which pyridine serves to stabilize the boryl radicals, generated in situ.

引用

收藏

页码：4759 / 4768

页数：10

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