Analysis of the pharmacokinetics and metabolism of aloe-emodin following intravenous and oral administrations in rats

被引：29

作者：

Yu, Chung-Ping ^{[1
]}

Shia, Chi-Sheng ^{[2
]}

Lin, Hui-Ju ^{[1
,3
]}

Hsieh, Yow-Wen ^{[2
,4
]}

Lin, Shiuan-Pey ^{[2
]}

Hou, Yu-Chi ^{[2
,4
]}

机构：

[1] China Med Univ, Sch Chinese Med, Taichung 404, Taiwan

[2] China Med Univ, Sch Pharm, Taichung 404, Taiwan

[3] China Med Univ Hosp, Dept Ophthalmol, Taichung 404, Taiwan

[4] China Med Univ Hosp, Dept Pharm, Taichung 404, Taiwan

来源：

BIOMEDICAL CHROMATOGRAPHY | 2016年 / 30卷 / 10期

关键词：

aloe-emodin; rhein; pharmacokinetics; metabolism; LC; MS; PERFORMANCE LIQUID-CHROMATOGRAPHY; VIVO ANTIOXIDANT ACTIVITY; MASS-SPECTROMETRY; P-GLYCOPROTEIN; ANTHRAQUINONES; BIOAVAILABILITY; RHUBARB; POLYPHENOLS; MACROPHAGES; DERIVATIVES;

D O I：

10.1002/bmc.3735

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Aloe-emodin, a natural polyphenolic anthraquinone, has shown various beneficial bioactivities in vitro. The aim of this study was to investigate the pharmacokinetics and metabolism of aloe-emodin. Aloe-emodin was intravenously and orally administered to rats. The concentrations of aloe-emodin and rhein, a metabolite of aloe-emodin, were determined by HPLC method prior to and after hydrolysis with -glucuronidase and sulfatase/-glucuronidase. The results showed that the systemic exposures of aloe-emodin and its metabolites were ranked as aloe-emodin glucuronides (G)>rhein sulfates (S)>aloe-emodin > rhein and rhein G when aloe-emodin was given intravenously. In contrast, when aloe-emodin was administered orally, the parent form of aloe-emodin was not absorbed per se, and the systemic exposures of its metabolites were ranked as aloe-emodin G>rhein G>rhein. In conclusion, the metabolites of aloe-emodin are more important than the parent form for the bioactivities in vivo. Copyright (c) 2016 John Wiley & Sons, Ltd.

引用

页码：1641 / 1647

页数：7

共 28 条

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