Autophagy and Liver Ischemia-Reperfusion Injury

被引:115
作者
Cursio, Raffaele [1 ,2 ]
Colosetti, Pascal [2 ]
Gugenheim, Jean [1 ]
机构
[1] Univ Nice Sophia Antipolis, Hop Archet 2, Serv Chirurg Digest & Transplantat Hepat, F-06200 Nice 3, France
[2] Univ Nice Sophia Antipolis, Equipe 2, Inserm U1065 C3M, F-06204 Nice 3, France
关键词
MITOCHONDRIAL PERMEABILITY TRANSITION; GROUP BOX 1; HEPATIC ISCHEMIA/REPERFUSION INJURY; ACTIVATED RECEPTOR-GAMMA; RAT-LIVER; COLD PRESERVATION; ENDOTHELIAL-CELLS; PROTEIN-KINASE; MEDIATED AUTOPHAGY; IMPAIRED AUTOPHAGY;
D O I
10.1155/2015/417590
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Liver ischemia-reperfusion (I-R) injury occurs during liver resection, liver transplantation, and hemorrhagic shock. The main mode of liver cell death after warm and/or cold liver I-R is necrosis, but other modes of cell death, as apoptosis and autophagy, are also involved. Autophagy is an intracellular self-digesting pathway responsible for removal of long-lived proteins, damaged organelles, and malformed proteins during biosynthesis by lysosomes. Autophagy is found in normal and diseased liver. Although depending on the type of ischemia, warm and/or cold, the dynamic process of liver I-R results mainly in adenosine triphosphate depletion and in production of reactive oxygen species (ROS), leads to both, a local ischemic insult and an acute inflammatory-mediated reperfusion injury, and results finally in cell death. This process can induce liver dysfunction and can increase patient morbidity and mortality after liver surgery and hemorrhagic shock. Whether autophagy protects from or promotes liver injury following warm and/or cold I-R remains to be elucidated. The present review aims to summarize the current knowledge in liver I-R injury focusing on both the beneficial and the detrimental effects of liver autophagy following warm and/or cold liver I-R.
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页数:16
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