Reduction of Overall Helicobacter pylori Colonization Levels in the Stomach of Mongolian Gerbil by Lactobacillus johnsonii La1 (LC1) and Its in Vitro Activities against H. pylori Motility and Adherence

被引：19

作者：

Isobe, Hirokazu ^{[1
]}

Nishiyama, Akihito ^{[1
]}

Takano, Tomomi ^{[1
]}

Higuchi, Wataru ^{[1
]}

Nakagawa, Saori ^{[1
]}

Taneike, Ikue ^{[1
]}

Fukushima, Yoichi ^{[2
]}

Yamamoto, Tatsuo ^{[1
]}

机构：

[1] Niigata Univ, Grad Sch Med & Dent Sci, Div Bacteriol, Dept Infect Dis Control & Int Med, Niigata 9518510, Japan

[2] Nestle Japan Ltd, Nutr Business Grp, Tokyo 1400002, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2012年 / 76卷 / 04期

关键词：

Lactobacillus johnsonii La1 (LC1); Helicobacter pylori; Mongolian gerbil; motility; adherence; PROBIOTICS; INGESTION;

D O I：

10.1271/bbb.110921

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of Lactobacillus johnsonii La1 (LC1) on Helicobacter pylori colonization in the stomach were investigated. H. pylori colonization and gastritis in LC1-inoculated Mongolian gerbils were significantly less intense than those in the control animals. LC1 culture supernatant (>10-kDa fraction) inhibited H. pylori motility and induced bacterial aggregation in human gastric epithelial cells, suggesting the potential of clinical use of LC1 product.

引用

页码：850 / 852

页数：3

共 5 条

[1] Modulation of Helicobacter pylori colonization with cranberry juice and Lactobacillus johnsonii La1 in children
Gotteland, Martin
Andrews, Monica
Toledo, Marcela
Munoz, Loreto
Caceres, Paola
Anziani, Alyerina
Wittig, Emma
Speisky, Heman
Salazar, Gabriela
NUTRITION, 2008, 24 (05) : 421 - 426
[2] Suppressive effect of frequent ingestion of Lactobacillus johnsonii La1 on Helicobacter pylori colonization in asymptomatic volunteers
Gotteland, M
Cruchet, S
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 51 (05) : 1317 - 1319
[3] Effect of the ingestion of a dietary product containing Lactobacillus johnsonii La1 on Helicobacter pylori colonization in children
Cruchet, S
Obregon, MC
Salazar, G
Diaz, E
Gotteland, M
NUTRITION, 2003, 19 (09) : 716 - 721
[4] Lactobacillus johnsonii La1 attenuates Helicobacter pylori-associated gastritis and reduces levels of proinflammatory chemokines in C57BL/6 mice
Sgouras, DN
Panayotopoulou, EG
Martinez-Gonzalez, B
Petraki, K
Michopoulos, S
Mentis, A
CLINICAL AND DIAGNOSTIC LABORATORY IMMUNOLOGY, 2005, 12 (12) : 1378 - 1386
[5] Lactobacillus johnsonii La1 attenuates Helicobacter pylori-associated gastritis and reduces the levels of proinflammatory cytokines in the gastric epithelium of C57BL/6 mice
Sgouras, DN
Panayotopoulou, E
Martinez-Gonzalez, B
Petraki, K
Michopoulos, S
Mentis, A
HELICOBACTER, 2005, 10 (05) : 491 - 491

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