In vitro assessment of chromosomal aberrations of cultured human peripheral blood lymphocyte following antiviral drug models exposure

被引：0

作者：

Elmonem, Walaa A. ^{[3
]}

Barakat, Ahmed B. ^{[4
]}

Shoman, Sahar A. ^{[4
]}

Dkhil, Mohamed A. ^{[1
,2
]}

Fahmy, Aly M. ^{[3
]}

机构：

[1] Helwan Univ, Fac Sci, Dept Zool, Cairo, Egypt

[2] King Saud Univ, Coll Sci, Dept Zool, Riyadh 11451, Saudi Arabia

[3] Egyptian Org Biol Prod & Vaccines, Giza, Egypt

[4] Ain Shams Univ, Fac Sci, Dept Microbiol, Cairo, Egypt

来源：

AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH | 2012年 / 6卷 / 10期

关键词：

Ribavirin; acyclovir; lymphocytes; chromosomal aberration; CHRONIC HEPATITIS-C; INITIAL TREATMENT; PLUS RIBAVIRIN; ACYCLOVIR; INTERFERON-ALPHA-2B;

D O I：

10.5897/AJMR11.1649

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ribavirin and acyclovir are two wide spectrum antiviral drugs. The present work aimed to draw attentions toward the cytotoxicity and genotoxicity of antiviral drugs. Also, it aimed to evaluate the cytogenetic/genotoxicity relatively to dose concentration (low, therapeutic, and high). Cytotoxicity of test antiviral drugs was carried out using human lymphocytes and macrophages. Ribavirin and Acyclovir were tested (low dose, 5 mu g/ml; therapeutic dose, 10 mu g/ml and high dose, 20 mu g/ml) against macrophage cells and human lymphocytes. Chromosomal aberrations were significantly recorded in human lymphocytes as tetrapolidy, pulverized metaphase and dicentric chromosomal aberrations. These aberrations due to Ribavirin post-treatment are dose dependant.

引用

页码：2517 / 2521

页数：5

共 27 条

[1] Chromosomal mosaicism in a pregnant woman treated with acyclovir for herpes simplex encephalitis [J].