Angiopoietin-2: a multifaceted cytokine that functions in both angiogenesis and inflammation

被引：196

作者：

Scholz, Alexander ^{[1
]}

Plate, Karl H. ^{[2
,3
,4
,5
]}

Reiss, Yvonne ^{[2
,3
,4
,5
]}

机构：

[1] Stanford Univ, Sch Med, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94304 USA

[2] Goethe Univ Frankfurt, Sch Med, Inst Neurol, Edinger Inst, D-60054 Frankfurt, Germany

[3] German Ctr Cardiovasc Res DZHK, Frankfurt, Germany

[4] German Canc Consortium DKTK, Frankfurt, Germany

[5] German Canc Res Ctr, Heidelberg, Germany

来源：

ANNALS REPORTS, VOL 1347 | 2015年 / 1347卷

关键词：

angiopoietin; Ang-2; inflammation; myeloid cell; innate immune cell; ENDOTHELIAL GROWTH-FACTOR; TIE-2 LIGAND ANGIOPOIETIN-2; TIE2-EXPRESSING MONOCYTES; RHEUMATOID-ARTHRITIS; VASCULAR LEAKAGE; SERUM-LEVELS; EXPRESSION; RECEPTOR; DISEASE; CELLS;

D O I：

10.1111/nyas.12726

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Angiogenesis and inflammation are two highly linked processes. In the last decade, several factors with dual function in both of these major pathways have been identified. This review focuses on angiopoietin-2 (Ang-2), an important proangiogenic factor that has more recently been implicated in mediating inflammatory processes as well. Ang-2 is upregulated inmultiple inflammatory diseases and has been implicated in the direct control of inflammation-related signaling pathways. As a consequence of itsmultiple roles, designs for therapeutic targeting of Ang-2 should consider the dual function of this factor in regulating angiogenesis and inflammation.

引用

页码：45 / 51

页数：7

共 72 条

[1] Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis [J].

Alfieri, Alessio ;

Watson, Jay J. ;

Kammerer, Richard A. ;

Tasab, Mohammed ;

Progias, Pavlos ;

Reeves, Kimberly ;

Brown, Nicola J. ;

Brookes, Zoe L. .

CRITICAL CARE, 2012, 16 (05)

[2] Vascular Endothelial Growth Factor-Angiopoietin Chimera With Improved Properties for Therapeutic Angiogenesis [J].

Anisimov, Andrey ;

Tvorogov, Denis ;

Alitalo, Annamari ;

Leppanen, Veli-Matti ;

An, Yuri ;

Han, Eun Chun ;

Orsenigo, Fabrizio ;

Gaal, Emilia Ilona ;

Holopainen, Tanja ;

Koh, Young Jun ;

Tammela, Tuomas ;

Korpisalo, Petra ;

Keskitalo, Salla ;

Jeltsch, Michael ;

Yla-Herttuala, Seppo ;

Dejana, Elisabetta ;

Koh, Gou Young ;

Choi, Chulhee ;

Saharinen, Pipsa ;

Alitalo, Kari .

CIRCULATION, 2013, 127 (04) :424-+

[3] Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system [J].

Augustin, Hellmut G. ;

Koh, Gou Young ;

Thurston, Gavin ;

Alitalo, Kari .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2009, 10 (03) :165-177

[4] Angiopoietin-1 decreases plasma leakage by reducing number and size of endothelial gaps in venules [J].

Baffert, F ;

Le, T ;

Thurston, G ;

McDonald, DM .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2006, 290 (01) :H107-H118

[5] Modes of resistance to anti-angiogenic therapy [J].

Bergers, Gabriele ;

Hanahan, Douglas .

NATURE REVIEWS CANCER, 2008, 8 (08) :592-603

[6] The role of angiopoietin 2 in hyperoxia-induced acute lung injury [J].

Bhandari, Vineet ;

Elias, Jack A. .

CELL CYCLE, 2007, 6 (09) :1049-1052

[7] Hyperoxia causes angiopoietin 2-mediated acute lung injury and necrotic cell death [J].

Bhandari, Vineet ;

Choo-Wing, Rayman ;

Lee, Chun G. ;

Zhu, Zhou ;

Nedrelow, Jonathan H. ;

Chupp, Geoffrey L. ;

Zhang, Xucher ;

Matthay, Michael A. ;

Ware, Lorraine B. ;

Homer, Robert J. ;

Lee, Patty J. ;

Geick, Anke ;

de Fougerolles, Antonin R. ;

Elias, Jack A. .

NATURE MEDICINE, 2006, 12 (11) :1286-1293

[8] Angiopoietin chemotactic activities on neutrophils are regulated by PI-3K activation [J].

Brkovic, Alexandre ;

Pelletier, Martin ;

Girard, Denis ;

Sirois, Martin G. .

JOURNAL OF LEUKOCYTE BIOLOGY, 2007, 81 (04) :1093-1101

[9] Angiopoietin 2 Stimulates TIE2-Expressing Monocytes To Suppress T Cell Activation and To Promote Regulatory T Cell Expansion [J].

Coffelt, Seth B. ;

Chen, Yung-Yi ;

Muthana, Munitta ;

Welford, Abigail F. ;

Tal, Andrea O. ;

Scholz, Alexander ;

Plate, Karl H. ;

Reiss, Yvonne ;

Murdoch, Craig ;

De Palma, Michele ;

Lewis, Claire E. .

JOURNAL OF IMMUNOLOGY, 2011, 186 (07) :4183-4190

[10] Angiopoietin-2 Regulates Gene Expression in TIE2-Expressing Monocytes and Augments Their Inherent Proangiogenic Functions [J].

Coffelt, Seth B. ;

Tal, Andrea O. ;

Scholz, Alexander ;

De Palma, Michele ;

Patel, Sunil ;

Urbich, Carmen ;

Biswas, Subhra K. ;

Murdoch, Craig ;

Plate, Karl H. ;

Reiss, Yvonne ;

Lewis, Claire E. .

CANCER RESEARCH, 2010, 70 (13) :5270-5280

← 1 2 3 4 5 6 7 8 →