Acute pressor and hormonal effects of β-endorphin at high doses in healthy and hypertensive subjects:: Role of opioid receptor agonism

被引：25

作者：

Cozzolino, D ^{[1
]}

Sasso, FC ^{[1
]}

Cataldo, D ^{[1
]}

Gruosso, D ^{[1
]}

Giammarco, A ^{[1
]}

Cavalli, A ^{[1
]}

Di Maggio, C ^{[1
]}

Renzo, G ^{[1
]}

Salvatore, T ^{[1
]}

Giugliano, D ^{[1
]}

Torella, R ^{[1
]}

机构：

[1] Univ Naples Federico II, Cardiovasc Res Ctr, I-80131 Naples, Italy

来源：

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2005年 / 90卷 / 09期

关键词：

D O I：

10.1210/jc.2004-2554

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Context: The opioid system is involved in blood pressure regulation in both normal humans and patients with essential hypertension. Objective: The objective of the study was to investigate the effects of a high-dose infusion of beta-endorphin, an opioid peptide, on blood pressure and on the hormonal profile in healthy subjects and in hypertensive patients and the mediation played by opioid receptor agonism. Design, Setting, and Participants: According to a randomized double-blind design, 11 healthy subjects ( controls) and 12 hypertensive inpatients ( mean age, 38.9 and 40.4 yr, respectively) received 1-h iv infusion of beta-endorphin (250 mu g/h) and, on another occasion, the same infusion protocol preceded by the opioid antagonist naloxone (8 mg). Main Outcome Measures: Hemodynamic and hormonal measurements were performed at established times during the infusion protocols. Results: At baseline, circulating beta-endorphin, norepinephrine, and endothelin-1 in hypertensive patients were significantly (P < 0.05) higher than in controls. In controls, beta-endorphin reduced blood pressure (P < 0.01) and circulating norepinephrine (P < 0.02) and increased plasma atrial natriuretic factor (P < 0.003) and GH (P < 0.0001). In hypertensive patients, beta-endorphin decreased systemic vascular resistance (P < 0.0001), blood pressure (P < 0.0001), and plasma norepinephrine (P < 0.0001) and endothelin-1 (P < 0.0001) and raised circulating atrial natriuretic factor (P < 0.0001), GH (P < 0.0001), and IGF-I (P < 0.0001). These hemodynamic and hormonal responses to beta-endorphin in hypertensive patients were significantly (P < 0.0001) greater than in controls but were annulled in all individuals when naloxone preceded beta-endorphin infusion. Conclusions: High doses of beta-endorphin induce hypotensive and beneficial hormonal effects in humans, which are enhanced in essential hypertension and are mediated by opioid receptors.

引用

页码：5167 / 5174

页数：8

共 27 条

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