Recent Advances in Glioma Cancer Treatment: Conventional and Epigenetic Realms

被引：20

作者：

Fath, Mohsen Karami ^{[1
]}

Babakhaniyan, Kimiya ^{[2
]}

Anjomrooz, Mehran ^{[3
]}

Jalalifar, Mohammadrasoul ^{[4
]}

Alizadeh, Seyed Danial ^{[4
]}

Pourghasem, Zeinab ^{[5
]}

Oshagh, Parisa Abbasi ^{[6
]}

Azargoonjahromi, Ali ^{[7
]}

Almasi, Faezeh ^{[8
,9
]}

Manzoor, Hafza Zahira ^{[10
]}

Khalesi, Bahman ^{[11
]}

Pourzardosht, Navid ^{[12
]}

Khalili, Saeed ^{[13
]}

Payandeh, Zahra ^{[14
]}

机构：

[1] Kharazmi Univ, Fac Biol Sci, Dept Cellular & Mol Biol, Tehran 1571914911, Iran

[2] Iran Univ Med Sci, Sch Nursing & Midwifery, Dept Med Surg Nursing, Tehran 1996713883, Iran

[3] Univ Tehran Med Sci, Shariati Hosp, Dept Radiol, Tehran 1411713135, Iran

[4] Kerman Univ Med Sci, Fac Med, Kerman 7616914115, Iran

[5] Islamic Azad Univ Lahijan, Dept Microbiol, Gilan 4416939515, Iran

[6] Malayer Univ, Fac Basic Sci, Dept Biol, Malayer 6571995863, Iran

[7] Shiraz Univ Med Sci, Sch Nursing & Midwifery, Dept Nursing, Shiraz 7417773539, Iran

[8] Univ Tehran, Coll Sci, Sch Biol, Pharmaceut Biotechnol Lab,Dept Microbial Biotechn, Tehran 1411734115, Iran

[9] Univ Tehran, Coll Sci, Ctr Excellence Phylogeny Living Organisms, Tehran 1411734115, Iran

[10] Univ Insubria, Expt & Translat Med, Via Jean Henry Dunant 3, I-21100 Varese, Italy

[11] Agr Res Educ & Extens Org, Razi Vaccine & Serum Res Inst, Dept Res & Prod Poultry Viral Vaccine, Karaj 3197619751, Iran

[12] Guilan Univ Med Sci, Fac Med, Cellular & Mol Res Ctr, Rasht 4193713111, Iran

[13] Shahid Rajaee Teacher Training Univ, Dept Biol Sci, Tehran 1678815811, Iran

[14] Karolinska Inst, Dept Med Biochem & Biophys, Div Med Inflammat Res, SE-17177 Stockholm, Sweden

来源：

VACCINES | 2022年 / 10卷 / 09期

关键词：

glioblastoma; cancer; brain tumor; treatment; epigenetic; peptide-based treatment; vaccine; DENDRITIC CELL VACCINATION; TUMOR-ASSOCIATED MACROPHAGES; PHASE-II TRIAL; RECURRENT GLIOBLASTOMA-MULTIFORME; ISLAND METHYLATOR PHENOTYPE; INTEGRATED GENOMIC ANALYSIS; CHIMERIC ANTIGEN RECEPTORS; LONG-TERM SURVIVAL; HIGH-GRADE GLIOMA; CAR T-CELLS;

D O I：

10.3390/vaccines10091448

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Glioblastoma (GBM) is the most typical and aggressive form of primary brain tumor in adults, with a poor prognosis. Successful glioma treatment is hampered by ineffective medication distribution across the blood-brain barrier (BBB) and the emergence of drug resistance. Although a few FDA-approved multimodal treatments are available for glioblastoma, most patients still have poor prognoses. Targeting epigenetic variables, immunotherapy, gene therapy, and different vaccine- and peptide-based treatments are some innovative approaches to improve anti-glioma treatment efficacy. Following the identification of lymphatics in the central nervous system, immunotherapy offers a potential method with the potency to permeate the blood-brain barrier. This review will discuss the rationale, tactics, benefits, and drawbacks of current glioma therapy options in clinical and preclinical investigations.

引用

页数：40

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