Intramolecular cyclization using palladium-catalyzed arylation toward formyl and nitro groups

被引：73
作者：
Muratake, H
Nakai, H
机构：
[1] Res Fdn Itsuu Lab, Setagaya Ku, Tokyo 1580094, Japan
[2] Shionogi & Co Ltd, Shionogi Res Labs, Fukushima Ku, Osaka 5530002, Japan
来源：
TETRAHEDRON LETTERS | 1999年 / 40卷 / 12期
关键词：
aldehydes; arylation; nitro compounds; palladium and compounds;
D O I：
10.1016/S0040-4039(99)00185-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Intramolecular arylation of properly designed substrates bearing a formyl or nitro terminating group was achieved employing a PdCl2(Ph3P)(2)-Cs2CO3 catalyst system to form various carbocyclic compounds. Arylation toward the formyl group occurred at the a-position (alpha-arylation) or at the carbonyl carbon (carbonyl-arylation) depending on the structure of the substrates and on the reaction solvent. The cl-arylated secondary nitro group was partially transformed to ketone, whereas the tertiary nitro group was partially eliminated to a styrene type of olefin. (C) 1999 Elsevier Science Ltd. All rights reserved.
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页码：2355 / 2358
页数：4
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