Healing effects of sumac (Rhus coriaria) in streptozotocin-induced diabetic rats

被引:53
作者
Dogan, Abdulahad [1 ]
Celik, Ismail [2 ]
机构
[1] Yuzuncu Yil Univ, Dept Biol, Fac Sci, TR-65080 Van, Turkey
[2] Yuzuncu Yil Univ, Dept Mol Biol & Genet, Fac Sci, Van, Turkey
关键词
alpha-Glucosidase; antidiabetic; antioxidant; hepatoprotective; OXIDATIVE STRESS; ANTIOXIDANT; L; EXTRACT; GLUCOSE;
D O I
10.3109/13880209.2016.1145702
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
Context Sumac [Rhus coriaria L. (RC) (Anacardiaceae)] is used as a folk medicine in the treatment of diabetes in Turkey. Objective This study investigates the in vivo healing and protective effects of lyophilized extract sumac against streptozotocin (STZ)-induced diabetic complications. Materials and methods Toxicity test was conducted in three different dosages (250, 500 and 1000 mg/kg of plant extracts, respectively). Six groups of seven rats each were used in experiments. Groups were designed as Normal control, Diabetic (DM), DM + AC-20 mg/kg, DM + Extract-100 mg/ kg, DM + Extract 250 mg/kg and DM + Extract 500 mg/kg group. Experimental diabetes [50 mg/kg, intraperitoneal (i.p.)] was induced by STZ. The effects of oral administration of the extract for 21 d on the level of serum glucose, insulin, C-peptide, lipid profile (LP), hepatic and renal damage biomarkers (HRDB), diabetic serum biomarkers (DSB), glycosylated haemoglobin (HbA1c), antioxidant defence system constituents (ADSCs), malondialdehyde (MDA) and alpha-glucosidase activity in small intestine tissue were evaluated. Results The extract decreased the levels of blood glucose in diabetic groups (an average of 31%). Triglyceride, total cholesterol, high-density lipoprotein and low-density lipoprotein levels were balanced by plant extract (500 mg/kg) supplementation in the diabetic group. Decreased levels of aspartate aminotransferase (89%), alanine aminotransferase (91%), lactate dehydrogenase (35%), alkaline phosphatase (47%), creatinine (25%) and urea (29%) were detected in plant extract (500 mg/kg) supplemented diabetic group. Additionally, a considerable increase in the HRDB, DSB, LP, MDA and fluctuated ADSC levels were restored in RC-extract supplemented groups. Conclusion RC lyophilized extract has a healing effect on diabetes and diabetes-related complications.
引用
收藏
页码:2092 / 2102
页数:11
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