New neo-clerodane diterpenoid alkaloids from Scutellaria barbata with cytotoxic activities

被引：46

作者：

Dai, Sheng-Jun ^{[1
]}

Liang, Dong-Dong ^{[1
]}

Ren, Yan ^{[1
]}

Liu, Ke ^{[1
]}

Shen, Li ^{[1
]}

机构：

[1] Yantai Univ, Sch Pharmaceut Sci, Yantai 264005, Peoples R China

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2008年 / 56卷 / 02期

关键词：

Scutellaria barbata; Labiatae; neo-clerodane diterpenoid alkaloid; scutebarbatine; cytotoxic activity;

D O I：

10.1248/cpb.56.207

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new neo-clerodane diterpenoid alkaloids, named scutebarbatines I-L (1-4), were isolated from the whole plant of Scutellaria barbata D. DON. Their structures were established on the basis of detailed spectral analyses. In vitro, the four new compounds showed significant cytotoxic activities against three human cancer lines (HONE-1 nasopharyngeal, KB oral epidermoid carcinoma, and HT29 colorectal carcinoma cells), and gave IC50 values in the range 3.2-8.3 mu M.

引用

页码：207 / 209

页数：3

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