Emergence of Ertapenem Resistance in an Escherichia coli Clinical Isolate Producing Extended-Spectrum β-Lactamase AmpC

被引：18
作者：
Guillon, Helene [1 ,2 ]
Tande, Didier [3 ]
Mammeri, Hedi [1 ,2 ]
机构：
[1] Univ Amiens, Serv Bacteriol, Ctr Hosp, Hop Nord, F-80000 Amiens, France
[2] Univ Picardie Jules Verne, Fac Med Amiens, F-80000 Amiens, France
[3] Univ Brest, Microbiol Serv, Hop Morvan, Ctr Hosp, F-29609 Brest, France
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2011年 / 55卷 / 09期
关键词：
KLEBSIELLA-PNEUMONIAE; CEPHALOSPORINASES; EXPRESSION; GENES;
D O I：
10.1128/AAC.01513-10
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Escherichia coli isolate MEV, responsible for a bloodstream infection, was resistant to penicillins, cephalosporins, and ertapenem. Molecular and biochemical characterization revealed the production of a novel, chromosome-borne, extended- spectrum AmpC (ESAC) beta-lactamase with a Ser-282 duplication and increased carbapenemase activity. This study demonstrates for the first time that chromosome-borne ESAC beta-lactamases can contribute to the emergence of ertapenem resistance in E. coli clinical isolates.
引用
收藏
页码：4443 / 4446
页数：4
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