Antibiotics in the clinical pipeline in 2011

被引：204
作者：
Butler, Mark S. [1 ]
Cooper, Matthew A. [1 ]
机构：
[1] Univ Queensland, Div Chem & Struct Biol, Inst Mol Biosci, Brisbane, Qld 4072, Australia
来源：
JOURNAL OF ANTIBIOTICS | 2011年 / 64卷 / 06期
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
clinical trials; drug development; drug discovery; natural product; resistance; IN-VITRO ACTIVITIES; PEPTIDE DEFORMYLASE INHIBITOR; CARRIER PROTEIN REDUCTASE; TRANSFER-RNA SYNTHETASE; DE-NOVO DESIGN; STAPHYLOCOCCUS-AUREUS; FABI INHIBITOR; LIPID-II; BAD BUGS; MYCOBACTERIUM-TUBERCULOSIS;
D O I：
10.1038/ja.2011.44
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The emergence of multi-drug-resistant bacteria and the lack of new antibiotics in the antibiotic drug development pipeline, especially those with new modes of action, is a major health concern. This review lists the 20 new antibiotics launched since 2000 and records the 40 compounds currently in active clinical development. Compounds in the pipeline from new antibiotic classes are reviewed in detail with reference to their development status, mode of action, spectrum of activity and lead discovery. In addition, the NP or synthetic derivation is discussed, with activity against Gram-negative bacteria highlighted. The Journal of Antibiotics (2011) 64, 413-425; doi:10.1038/ja.2011.44; published online 18 May 2011
引用
收藏
页码：413 / 425
页数：13
相关论文
共 201 条
[81]   Comparative Antipneumococcal Activities of Sulopenem and Other Drugs [J].
Kosowska-Shick, Klaudia ;
Ednie, Lois M. ;
McGhee, Pamela ;
Appelbaum, Peter C. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (06) :2239-2247
[82]   Diarylquinolines are bactericidal for dormant mycobacteria as a result of disturbed ATP homeostasis [J].
Koul, Anil ;
Vranckx, Luc ;
Dendouga, Najoua ;
Balemans, Wendy ;
Van den Wyngaert, Ilse ;
Vergauwen, Karen ;
Goehlmann, Hinrich W. H. ;
Willebrords, Rudy ;
Poncelet, Alain ;
Guillemont, Jerome ;
Bald, Dirk ;
Andries, Koen .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (37) :25273-25280
[83]   Diarylquinolines target subunit c of mycobacterial ATP synthase [J].
Koul, Anil ;
Dendouga, Najoua ;
Vergauwen, Karen ;
Molenberghs, Brenda ;
Vranckx, Luc ;
Willebrords, Rudy ;
Ristic, Zorica ;
Lill, Holger ;
Dorange, Ismet ;
Guillemont, Jerome ;
Bald, Dirk ;
Andries, Koen .
NATURE CHEMICAL BIOLOGY, 2007, 3 (06) :323-324
[84]   The challenge of new drug discovery for tuberculosis [J].
Koul, Anil ;
Arnoult, Eric ;
Lounis, Nacer ;
Guillemont, Jerome ;
Andries, Koen .
NATURE, 2011, 469 (7331) :483-490
[85]   Multicenter, Randomized Study of the Efficacy and Safety of Intravenous Iclaprim in Complicated Skin and Skin Structure Infections [J].
Krievins, D. ;
Brandt, R. ;
Hawser, S. ;
Hadvary, P. ;
Islam, K. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (07) :2834-2840
[86]   Lipiarmycin targets RNA polymerase and has good activity against multidrug-resistant strains of Mycobacterium tuberculosis [J].
Kurabachew, Mekonnen ;
Lu, Stephen H. J. ;
Krastel, Philipp ;
Schmitt, Esther K. ;
Suresh, Bangalore L. ;
Goh, Anne ;
Knox, John E. ;
Ma, Ngai Ling ;
Jiricek, Jan ;
Beer, David ;
Cynamon, Michael ;
Petersen, Frank ;
Dartois, Veronique ;
Keller, Thomas ;
Dick, Thomas ;
Sambandamurthy, Vasan K. .
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2008, 62 (04) :713-719
[87]   Comparative In Vitro Activities of Nemonoxacin (TG-873870), a Novel Nonfluorinated Quinolone, and Other Quinolones against Clinical Isolates [J].
Lauderdale, Tsai-Ling ;
Shiau, Yih-Ru ;
Lai, Jui-Fen ;
Chen, Hua-Chien ;
King, Chi-Hsin R. .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (03) :1338-1342
[88]   Peptide deformylase as an antibacterial target: a critical assessment [J].
Leeds, Jennifer A. ;
Dean, Charles R. .
CURRENT OPINION IN PHARMACOLOGY, 2006, 6 (05) :445-452
[89]   Contrasting Effects of Acidic pH on the Extracellular and Intracellular Activities of the Anti-Gram-Positive Fluoroquinolones Moxifloxacin and Delafloxacin against Staphylococcus aureus [J].
Lemaire, Sandrine ;
Tulkens, Paul M. ;
Van Bambeke, Francoise .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2011, 55 (02) :649-658
[90]   Cellular Pharmacodynamics of the Novel Biaryloxazolidinone Radezolid: Studies with Infected Phagocytic and Nonphagocytic cells, Using Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Legionella pneumophila [J].
Lemaire, Sandrine ;
Kosowska-Shick, Klaudia ;
Appelbaum, Peter C. ;
Verween, Gunther ;
Tulkens, Paul M. ;
Van Bambeke, Francoise .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (06) :2549-2559
45678910111213