To establish the dependence of the influence of tillage and fertilization system in the conditions of short-rotation grain-fallow-cultivated crop rotation on the degree of weediness of winter wheat is the aim of the paper. Field and laboratory methods were used. The research was carried out in a long-term out-station experiment of Veselopodilsk research and selection station, on typical low-alkalinized chornozem black soil. The use of combined tillage contributed to the growth of weediness of crops, where in the unfertilized version there were 50.3 pcs/m(2), while using the plowing 46.8 pcs/m(2) were observed. When using the organic-mineral fertilization system 21.9 pcs/m(2) in combined tillage, and 16.4 pcs/m(2) in plowing were counted. When plowing post-harvest residues, an increase in the number of weeds was observed due to the use of plowing - 23.7 pcs./m(2), and the use of combined tillage - 20.8 pcs/m(2). Plowing contributed to the appearance of fewer weeds than in combined tillage, both in the unfertilized plot and with the use of organic-mineral fertilization system by 3.7 and 5.5 pcs/m(2), respectively. Plowing of post-harvest residues on the background of mineral fertilizing during plowing increased by 2.9 pcs/m(2) compared to combined tillage. The use of fertilizers significantly reduced weediness of crops, regardless of the type of tillage.