COPs and POPs Patrol Inflammasome Activation

被引：45

作者：

Indramohan, Mohanalaxmi ^{[1
]}

Stehlik, Christian ^{[1
,2
,3
]}

Dorfleutner, Andrea ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Dept Med, Div Rheumatol, Chicago, IL 60611 USA

[2] Northwestern Univ, Feinberg Sch Med, Interdept Immunobiol Ctr, Robert H Lurie Comprehens Canc Ctr, Chicago, IL 60611 USA

[3] Northwestern Univ, Feinberg Sch Med, Skin Dis Res Ctr, Chicago, IL 60611 USA

来源：

JOURNAL OF MOLECULAR BIOLOGY | 2018年 / 430卷 / 02期

基金：

美国国家卫生研究院;

关键词：

inflammasome; Caspase-1; IL-1; beta; PYD-only protein; CARD-only protein; NF-KAPPA-B; LEUCINE-RICH REPEAT; PATTERN-RECOGNITION RECEPTORS; DOMAIN-ONLY PROTEIN; PYRIN DOMAIN; NLRP3; INFLAMMASOME; RECRUITMENT DOMAIN; ATP-BINDING; GASDERMIN-D; AIM2;

D O I：

10.1016/j.jmb.2017.10.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sensing and responding to pathogens and tissue damage is a core mechanism of innate immune host defense, and inflammasomes represent a central cytosolic pattern recognition receptor pathway leading to the generation of the pro-inflammatory cytokines interleukin-1 beta and interleukin-18 and pyroptotic cell death that causes the subsequent release of danger signals to propagate and perpetuate inflammatory responses. While inflammasome activation is essential for host defense, deregulated inflammasome responses and excessive release of inflammatory cytokines and danger signals are linked to an increasing spectrum of inflammatory diseases. In this review, we will discuss recent developments in elucidating the role of PYRIN domain-only proteins (POPs) and the related CARD-only proteins (COPs) in regulating inflammasome responses and their impact on inflammatory disease. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：153 / 173

页数：21

共 200 条

[1] The mitochondrial apoptosome: a killer unleashed by the cytochrome seas [J].

Adrain, C ;

Martin, SJ .

TRENDS IN BIOCHEMICAL SCIENCES, 2001, 26 (06) :390-397

[2] GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes [J].

Aglietti, Robin A. ;

Estevez, Alberto ;

Gupta, Aaron ;

Ramirez, Monica Gonzalez ;

Liu, Peter S. ;

Kayagaki, Nobuhiko ;

Ciferri, Claudio ;

Dixit, Vishva M. ;

Dueber, Erin C. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2016, 113 (28) :7858-7863

[3] NALP3 forms an IL-lβ-Processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder [J].

Agostini, L ;

Martinon, F ;

Burns, K ;

McDermott, MF ;

Hawkins, PN ;

Tschopp, J .

IMMUNITY, 2004, 20 (03) :319-325

[4] Control of the innate immune response by the mevalonate pathway [J].

Akula, Murali K. ;

Shi, Man ;

Jiang, Zhaozhao ;

Foster, Celia E. ;

Miao, David ;

Li, Annie S. ;

Zhang, Xiaoman ;

Gavin, Ruth M. ;

Forde, Sorcha D. ;

Germain, Gail ;

Carpenter, Susan ;

Rosadini, Charles V. ;

Gritsman, Kira ;

Chae, Jae Jin ;

Hampton, Randolph ;

Silverman, Neal ;

Gravallese, Ellen M. ;

Kagan, Jonathan C. ;

Fitzgerald, Katherine A. ;

Kastner, Daniel L. ;

Golenbock, Douglas T. ;

Bergo, Martin O. ;

Wang, Donghai .

NATURE IMMUNOLOGY, 2016, 17 (08) :922-+

[5] Uncoupling of Pyrin-only Protein 2 (POP2)-mediated Dual Regulation of NF-κB and the Inflammasome [J].

Atianand, Maninjay K. ;

Harton, Jonathan A. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 286 (47) :40536-40547

[6] Novel isoforms of the CARD8 (TUCAN) gene evade a nonsense mutation [J].

Bagnall, Richard D. ;

Roberts, Roland G. ;

Mirza, Muddassar M. ;

Torigoe, Toshihiko ;

Prescott, Natalie J. ;

Mathew, Christopher G. .

EUROPEAN JOURNAL OF HUMAN GENETICS, 2008, 16 (05) :619-625

[7] The NLRP3 inflammasome is released as a particulate danger signal that amplifies the inflammatory response [J].

Baroja-Mazo, Alberto ;

Martin-Sanchez, Fatima ;

Gomez, Ana I. ;

Martinez, Carlos M. ;

Amores-Iniesta, Joaquin ;

Compan, Vincent ;

Barbera-Cremades, Maria ;

Yaguee, Jordi ;

Ruiz-Ortiz, Estibaliz ;

Anton, Jordi ;

Bujan, Segundo ;

Couillin, Isabelle ;

Brough, David ;

Arostegui, Juan I. ;

Pelegrin, Pablo .

NATURE IMMUNOLOGY, 2014, 15 (08) :738-+

[8] Of inflammasomes and pathogens - sensing of microbes by the inflammasome [J].

Bauernfeind, Franz ;

Hornung, Veit .

EMBO MOLECULAR MEDICINE, 2013, 5 (06) :814-826

[9] Inflammasomes: current understanding and open questions [J].

Bauernfeind, Franz ;

Ablasser, Andrea ;

Bartok, Eva ;

Kim, Sarah ;

Schmid-Burgk, Jonathan ;

Cavlar, Taner ;

Hornung, Veit .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2011, 68 (05) :765-783

[10] Pyrin-only protein 2 modulates NFκB and disrupts ASC:CLR interactions [J].

Bedoya, Felipe ;

Sandler, Laurel L. ;

Harton, Jonathan A. .

JOURNAL OF IMMUNOLOGY, 2007, 178 (06) :3837-3845

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