Chitosan Nanoparticles Containing Lipoic Acid with Antioxidant Properties as a Potential Nutritional Supplement

被引：9

作者：

Quester, Katrin ^{[1
]}

Rodriguez-Gonzalez, Sarahi ^{[2
]}

Gonzalez-Davalos, Laura ^{[2
]}

Lozano-Flores, Carlos ^{[2
]}

Gonzalez-Gallardo, Adriana ^{[3
]}

Zapiain-Merino, Santino J. ^{[1
]}

Shimada, Armando ^{[2
]}

Mora, Ofelia ^{[2
]}

Vazquez-Duhalt, Rafael ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Ctr Nanociencias & Nanotecnol, Km 107 Carretera Tijuana Ensenada, Ensenada 22860, Baja California, Mexico

[2] Univ Nacl Autonoma Mexico, Lab Rumiol & Metab Nutr RuMeN, FES C, Blvd Juriquilla 3001, Queretaro 76230, Mexico

[3] Univ Nacl Autonoma Mexico, Inst Neurobiol, Blvd Juriquilla 3001, Queretaro 76230, Mexico

来源：

ANIMALS | 2022年 / 12卷 / 04期

关键词：

antioxidant; cell internalization; chitosan nanoparticles; everted intestine; lipoic acid; SURFACE-CHARGE; DOUBLE-BLIND; OXIDATIVE STRESS; GLUCOSE-UPTAKE; PLACEBO; DRUG; WEIGHT; TRANSLOCATION; PERFORMANCE; ACTIVATION;

D O I：

10.3390/ani12040417

中图分类号：

S8 [畜牧、动物医学、狩猎、蚕、蜂];

学科分类号：

0905 ;

摘要：

Simple Summary Alfa-lipoic acid (ALA) is an important antioxidant that could be added to animal feed as a nutritional supplement. To improve its stability in the digestive system, ALA was encapsulated in chitosan nanoparticles. The nanoparticles containing ALA were stable in stomach-like conditions and were able to cross the intestinal barrier. Chitosan-based nanoparticles seem to be an attractive administration method for antioxidants, or other sensible additives, in food. The addition of the antioxidant alpha-lipoic acid (ALA) to a balanced diet might be crucial for the prevention of comorbidities such as cardiovascular diseases, diabetes, and obesity. Due to its low half-life and instability under stomach-like conditions, alpha-lipoic acid was encapsulated into chitosan nanoparticles (Ch-NPs). The resulting chitosan nanoparticles containing 20% w/w ALA (Ch-ALA-NPs) with an average diameter of 44 nm demonstrated antioxidant activity and stability under stomach-like conditions for up to 3 h. Furthermore, fluorescent Ch-ALA-NPs were effectively internalized into 3T3-L1 fibroblasts and were able to cross the intestinal barrier, as evidenced by everted intestine in vitro experiments. Thus, chitosan-based nanoparticles seem to be an attractive administration method for antioxidants, or other sensible additives, in food.

引用

页数：13