Canonical Wnt Signaling in the Pathology of Iron Overload-Induced Oxidative Stress and Age-Related Diseases

被引：8
作者：
Armstrong, Austin [1 ,2 ]
Mandala, Ashok [1 ,2 ]
Malhotra, Milan [1 ,2 ]
Gnana-Prakasam, Jaya P. [1 ,2 ]
机构：
[1] St Louis Univ, Dept Ophthalmol, St Louis, MO 63103 USA
[2] St Louis Univ, Dept Biochem & Mol Biol, St Louis, MO 63103 USA
来源：
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2022年 / 2022卷
关键词：
RECEPTOR-RELATED PROTEIN-5; WNT/BETA-CATENIN PATHWAY; MAMMARY-TUMOR VIRUS; RETINAL-PIGMENT EPITHELIUM; BETA-CATENIN; GROWTH-FACTOR; DIETARY IRON; FUNCTIONAL INTERACTION; RETROGRADE TRANSPORT; VASCULAR DEVELOPMENT;
D O I：
10.1155/2022/7163326
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Iron accumulates in the vital organs with aging. This is associated with oxidative stress, inflammation, and mitochondrial dysfunction leading to age-related disorders. Abnormal iron levels are linked to neurodegenerative diseases, liver injury, cancer, and ocular diseases. Canonical Wnt signaling is an evolutionarily conserved signaling pathway that regulates many cellular functions including cell proliferation, apoptosis, cell migration, and stem cell renewal. Recent evidences indicate that iron regulates Wnt signaling, and iron chelators like deferoxamine and deferasirox can inhibit Wnt signaling and cell growth. Canonical Wnt signaling is implicated in the pathogenesis of many diseases, and there are significant efforts ongoing to develop innovative therapies targeting the aberrant Wnt signaling. This review examines how intracellular iron accumulation regulates Wnt signaling in various tissues and their potential contribution in the progression of age-related diseases.
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页数：13
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