Metal-Based Nanoparticles and the Immune System: Activation, Inflammation, and Potential Applications

被引：183

作者：

Luo, Yueh-Hsia ^{[1
]}

Chang, Louis W. ^{[2
]}

Lin, Pinpin ^{[1
,2
]}

机构：

[1] Natl Hlth Res Inst, Div Environm Hlth & Occupat Med, Zhunan 35053, Miaoli County, Taiwan

[2] Natl Hlth Res Inst, Natl Environm Hlth Res Ctr, Zhunan 35053, Miaoli County, Taiwan

来源：

BIOMED RESEARCH INTERNATIONAL | 2015年 / 2015卷

关键词：

TOLL-LIKE RECEPTOR; IN-VITRO CYTOTOXICITY; ZINC-OXIDE NANOPARTICLE; NATURAL-KILLER-CELLS; SILVER NANOPARTICLES; TISSUE DISTRIBUTION; NLRP3; INFLAMMASOME; ENGINEERED NANOPARTICLES; NALP3; OXIDATIVE STRESS;

D O I：

10.1155/2015/143720

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Nanomaterials, including metal-based nanoparticles, are used for various biological and medical applications. However, metals affect immune functions in many animal species including humans. Different physical and chemical properties induce different cellular responses, such as cellular uptake and intracellular biodistribution, leading to the different immune responses. The goals of this review are to summarize and discuss the innate and adaptive immune responses triggered by metal-based nanoparticles in a variety of immune system models.

引用

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