RAPID ENTEROVIRUS MOLECULAR TESTING IN CEREBROSPINAL FLUID REDUCES LENGTH OF HOSPITALIZATION AND DURATION OF ANTIBIOTIC THERAPY IN CHILDREN WITH ASEPTIC MENINGITIS

被引：15

作者：

Huizing, Kirsten M. N. ^{[1
]}

Swanink, Caroline M. A. ^{[2
]}

Landstra, Anneke M. ^{[1
]}

van Zwet, Anton A. ^{[2
]}

van Setten, Petra A. ^{[1
]}

机构：

[1] Rijnstate Hosp Arnhem, Dept Paediat, NL-6800 TA Arnhem, Netherlands

[2] Rijnstate Hosp Arnhem, Dept Med Microbiol & Immunol, NL-6800 TA Arnhem, Netherlands

来源：

PEDIATRIC INFECTIOUS DISEASE JOURNAL | 2011年 / 30卷 / 12期

关键词：

rapid enterovirus molecular test; aseptic meningitis; child; health savings; POLYMERASE-CHAIN-REACTION; CLINICAL SPECIMENS; INFANTS; IMPACT;

D O I：

10.1097/INF.0b013e31822cca1f

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied the potential benefits of introducing a rapid enterovirus molecular test in children with enterovirus meningitis. The 2 groups of pediatric patients were comparable with respect to clinical and laboratory data, but differed in availability of enterovirus test results. In the control group, the results were available within 3 to 7 days, whereas in the study group, rapid enterovirus molecular test results were available within 3 to 24 hours. The median duration of hospitalization and the duration of antibiotics were significantly reduced to, respectively, 2 days and 1 day in the study group when compared with the control group (P < 0.001). Mean costs per patient calculation showed an average reduction of more than US $1450 (P < 0.001).

引用

页码：1107 / 1109

页数：4

共 7 条

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[2] Enterovirus-D68 in the Cerebrospinal Fluid of Two Children with Aseptic Meningitis
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PEDIATRIC INFECTIOUS DISEASE JOURNAL, 2016, 35 (05) : 589 - 591
[3] Routine cerebrospinal fluid enterovirus polymerase chain reaction testing reduces hospitalization and antibiotic use for infants 90 days of age or younger
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PEDIATRICS, 2007, 120 (03) : 489 - 496
[4] Rapid detection of enterovirus in cerebrospinal fluid by a fully-automated PCR assay is associated with improved management of aseptic meningitis in adult patients
Giulieri, Stefano G.
Chapuis-Taillard, Caroline
Manuel, Oriol
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JOURNAL OF CLINICAL VIROLOGY, 2015, 62 : 58 - 62
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Archimbaud, C.
Chambon, M.
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JOURNAL OF MEDICAL VIROLOGY, 2009, 81 (01) : 42 - 48
[6] Analysis of enterovirus genotypes in the cerebrospinal fluid of children associated with aseptic meningitis in Liaocheng, China, from 2018 to 2019
Wang, Jing
Meng, Min
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Yan, Han
Liu, Peiman
Qin, Daogang
Yang, Qiaozhi
BMC INFECTIOUS DISEASES, 2021, 21 (01)
[7] Analysis of enterovirus genotypes in the cerebrospinal fluid of children associated with aseptic meningitis in Liaocheng, China, from 2018 to 2019
Jing Wang
Min Meng
Huan Xu
Ting Wang
Ying Liu
Han Yan
Peiman Liu
Daogang Qin
Qiaozhi Yang
BMC Infectious Diseases, 21

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