Vitamin E as a Treatment for Nonalcoholic Fatty Liver Disease: Reality or Myth?

被引：111

作者：

El Hadi, Hamza ^{[1
]}

Vettor, Roberto ^{[1
]}

Rossato, Marco ^{[1
]}

机构：

[1] Univ Padua, Dept Med DIMED, Internal Med 3, Via Giustiniani 2, I-35128 Padua, Italy

来源：

ANTIOXIDANTS | 2018年 / 7卷 / 01期

关键词：

vitamin E; nonalcoholic fatty liver disease; obesity; oxidative stress; ALPHA-TOCOPHEROL; INSULIN-RESISTANCE; OXIDATIVE STRESS; URSODEOXYCHOLIC ACID; E SUPPLEMENTATION; CONTROLLED-TRIAL; STEATOHEPATITIS; ANTIOXIDANT; CHILDREN; GAMMA;

D O I：

10.3390/antiox7010012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Obesity is one of the major epidemics of this millennium, and its incidence is growing worldwide. Following the epidemics of obesity, nonalcoholic fatty liver disease (NAFLD) has become a disease of increasing prevalence and a leading cause of morbidity and mortality closely related to cardiovascular disease, malignancies, and cirrhosis. It is believed that oxidative stress is a main player in the development and progression of NAFLD. Currently, a pharmacological approach has become necessary in NAFLD because of a failure to modify lifestyle and dietary habits in most patients. Vitamin E is a potent antioxidant that has been shown to reduce oxidative stress in NAFLD. This review summarizes the biological activities of vitamin E, with a primary focus on its therapeutic efficacy in NAFLD.

引用

页数：13

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