Women in early-phase clinical drug trials:: Have things changed over the past 20 years?

被引:29
作者
Fleisch, J
Fleisch, MC
Thürmann, PA
机构
[1] Univ Witten Herdecke, Chair Clin Pharmacol, HELIOS Klinikum Wuppertal, Philipp Klee Inst Clin Pharmacol, D-42283 Wuppertal, Germany
[2] Univ Dusseldorf, Dept Obstet & Gynecol, D-4000 Dusseldorf, Germany
关键词
D O I
10.1016/j.clpt.2005.08.016
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:445 / 452
页数:8
相关论文
共 57 条
[1]   Stereoselective halofantrine disposition and effect: concentration-related QTc prolongation [J].
Abernethy, DR ;
Wesche, DL ;
Barbey, JT ;
Ohrt, C ;
Mohanty, S ;
Pezzullo, JC ;
Schuster, BG .
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2001, 51 (03) :231-237
[2]   Acetaminophen analgesia in children: placebo effect and pain resolution after tonsillectomy [J].
Anderson, BJ ;
Woollard, GA ;
Holford, NHG .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2001, 57 (08) :559-569
[3]  
ANSHELEVICH M, 1994, LANCET, V344, P91
[4]   Clinical pharmacology - Special safety considerations in drug development and pharmacovigilance [J].
Atuah, KN ;
Hughes, D ;
Pirmohamed, M .
DRUG SAFETY, 2004, 27 (08) :535-554
[5]  
BANDYOPADHYAY S, 2000, QJM, V94, P127
[6]   Effect of grapefruit juice on digoxin pharmacokinetics in humans [J].
Becquemont, L ;
Verstuyft, C ;
Kerb, R ;
Brinkmann, U ;
Lebot, M ;
Jaillon, P ;
Funck-Brentano, C .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 70 (04) :311-316
[7]   Duplication of CYP2D6 predicts high clearance of desipramine but high clearance does not predict duplication of CYP2D6 [J].
Bergmann, TK ;
Bathum, L ;
Brosen, K .
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 2001, 57 (02) :123-127
[8]   Disposition and pharmacologic effects of R/S-verapamil in patients with chronic atrial fibrillation:: An investigation comparing single and multiple dosing [J].
Busse, D ;
Fromm, MF ;
Mörike, K ;
Drescher, S ;
Kühlkamp, V ;
Eichelbaum, M .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2001, 69 (05) :324-332
[9]   Pharmacokinetic analysis of bioequivalence trials: Implications for sex-related issues in clinical pharmacology and biopharmaceutics [J].
Chen, ML ;
Lee, SC ;
Ng, MJ ;
Schuirmann, DJ ;
Lesko, LJ ;
Williams, RL .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2000, 68 (05) :510-521
[10]   The influence of age and sex on the clearance of cytochrome P450 3A substrates [J].
Cotreau, MM ;
von Moltke, LL ;
Greenblatt, DJ .
CLINICAL PHARMACOKINETICS, 2005, 44 (01) :33-60