Effects of clove (Caryophyllus aromaticus L.) on the labeling of blood constituents with technetium-99m and on the morphology of red blood cells

被引：5

作者：

de Paoli, Severo ^{[1
,2
,4
,5
]}

Giani, Tania Santos ^{[1
,2
,4
]}

Presta, Giuseppe Antonio ^{[1
,2
]}

Pereira, Marcia Oliveira ^{[2
,4
]}

da Fonseca, Adenilson de Souza ^{[2
,5
]}

Brandao-Neto, Jose ^{[1
]}

Medeiros, Aldo da Cunha ^{[1
]}

Santos-Filho, Sebastiao David ^{[1
,2
]}

Bernardo-Filho, Mario ^{[2
,3
]}

机构：

[1] Univ Fed Rio Grande do Norte, Programa Posgrad Ciencias Saude, BR-59010180 Natal, RN, Brazil

[2] Univ Estado Rio de Janeiro, Inst Biol Roberto Alcantara Gomes, Dept Biofis & Biometria, BR-20551030 Rio De Janeiro, Brazil

[3] Inst Nacl Canc, BR-20230130 Rio De Janeiro, Brazil

[4] Univ Estacio Sa, BR-20261063 Rio De Janeiro, Brazil

[5] Ctr Univ Fundacao Educ Serra Orgaos, Fac Odontol & Fisioterapia, BR-25964004 Teresopolis, RJ, Brazil

来源：

BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY | 2007年 / 50卷

关键词：

technetium-99m; blood constituents; red blood cells; morphology; Caryophyllus aromaticus L;

D O I：

10.1590/S1516-89132007000600022

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Clove (Caryophyllus aromaticus L.) has been used for clinical procedures. Blood constituents labeled with technetium-99m (99mTc) are used in nuclear medicine. The aim of this work was to evaluate the effects of clove extract on the labeling blood constituents with 99mTc and on the morphology of red blood cells. Blood samples were incubated with clove, stannous chloride and 99mTc. Plasma, blood cells, insoluble fractions of plasma and blood cells were separated. The radioactivity was counted and percentage of radioactivity (%ATI) to each blood fraction was calculated. The shape and morphometric parameter (perimeter/area ratio) were evaluated. Clove extract altered significantly (p< 0.05) the %ATI of blood constituents and the shape of red blood cells without modifying the perimeter/area ratio. The results indicate that clove extract presents chemical compounds that interfere with the radiolabeling of blood constituents and alter the morphology of red blood cells by oxidative/chelating actions or interacting with the cellular membrane structure.

引用

页码：175 / 182

页数：8

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