Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: do adipocytes consume sufficient amounts of oxygen to oxidise fatty acids?

被引：10
作者：
Maassen, J. A. [1 ,2 ]
Romijn, J. A. [3 ]
Heine, R. J. [2 ,4 ]
机构：
[1] Leiden Univ, Med Ctr, Dept Mol Cell Biol, NL-2300 RC Leiden, Netherlands
[2] Vrije Univ Amsterdam, Dept Endocrinol, Ctr Diabet, Med Ctr, Amsterdam, Netherlands
[3] Leiden Univ, Med Ctr, Dept Endocrinol & Metab Dis, Leiden, Netherlands
[4] Eli Lilly & Co, Lilly Corp Ctr, Indianapolis, IN 46285 USA
来源：
DIABETOLOGIA | 2008年 / 51卷 / 05期
关键词：
adipocytes; fatty acids; HAART; mitochondria; type 2 diabetes mellitus;
D O I：
10.1007/s00125-008-0963-6
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：907 / 908
页数：2
相关论文
共 10 条
[1]  
Baril Jean-Guy, 2005, Can J Infect Dis Med Microbiol, V16, P233
[2]   Mitochondrial toxicity induced by nucleoside-analogue reverse-transcriptase inhibitors is a key factor in the pathogenesis of antiretroviral-therapy-related lipodystrophy [J].
Brinkman, K ;
Smeitink, JA ;
Romijn, JA ;
Reiss, P .
LANCET, 1999, 354 (9184) :1112-1115
[3]   Diseases of adipose tissue:: genetic and acquired lipodystrophies [J].
Capeau, J ;
Magré, J ;
Lascols, O ;
Caron, M ;
Béréziat, V ;
Vigouroux, C ;
Bastard, JP .
BIOCHEMICAL SOCIETY TRANSACTIONS, 2005, 33 :1073-1077
[4]   POSTPRANDIAL SUBSTRATE DEPOSITION IN HUMAN FOREARM AND ADIPOSE TISSUES INVIVO [J].
COPPACK, SW ;
FISHER, RM ;
GIBBONS, GF ;
HUMPHREYS, SM ;
MCDONOUGH, MJ ;
POTTS, JL ;
FRAYN, KN .
CLINICAL SCIENCE, 1990, 79 (04) :339-348
[5]  
FRAYN KN, 2008, IN PRESS DIABETOLOGI
[6]   INFLUENCE OF AGE, FAT-CELL WEIGHT, AND OBESITY ON O-2 CONSUMPTION OF HUMAN ADIPOSE-TISSUE [J].
HALLGREN, P ;
SJOSTROM, L ;
HEDLUND, H ;
LUNDELL, L ;
OLBE, L .
AMERICAN JOURNAL OF PHYSIOLOGY, 1989, 256 (04) :E467-E474
[7]   Strong association between mitochondrial DNA copy number and lipogenesis in human white adipose tissue [J].
Kaaman, M. ;
Sparks, L. M. ;
van Harmelen, V. ;
Smith, S. R. ;
Sjoelin, E. ;
Dahlman, I. ;
Arner, P. .
DIABETOLOGIA, 2007, 50 (12) :2526-2533
[8]   Fatty acid-induced mitochondrial uncoupling in adipocytes as a key protective factor against insulin resistance and beta cell dysfunction: a new concept in the pathogenesis of obesity-associated type 2 diabetes mellitus [J].
Maassen, J. A. ;
Romijn, J. A. ;
Heine, R. J. .
DIABETOLOGIA, 2007, 50 (10) :2036-2041
[9]   Unexpected evidence for active brown adipose tissue in adult humans [J].
Nedergaard, Jan ;
Bengtsson, Tore ;
Cannon, Barbara .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 2007, 293 (02) :E444-E452
[10]  
SJOSTROM L, 1971, J LIPID RES, V12, P521
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