Chemical composition and antigenotoxic properties of Lippia alba essential oils

被引：47
作者：
Andrea Lopez, Molkary [1 ]
Stashenko, Elena E. [2 ]
Luis Fuentes, Jorge [1 ,2 ]
机构：
[1] Ind Univ Santander, Microbiol & Environm Mutagenesis Lab, Sch Biol, Fac Sci, Bucaramanga 678, Colombia
[2] Ind Univ Santander, Res Ctr Biomol, Res Ctr Excellence, Bucaramanga 678, Colombia
来源：
GENETICS AND MOLECULAR BIOLOGY | 2011年 / 34卷 / 03期
关键词：
Lippia alba; essential oil; antigenotoxicity; bleomycin; SOS chromotest; MILL. NE BROWN; ESCHERICHIA-COLI; IN-VITRO; ANTIOXIDANT; CHEMOTYPES; TERPENES; OFFICINALIS; INHIBITION; PRINCIPLES; TOXICITY;
D O I：
10.1590/S1415-47572011005000030
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The present work evaluated the chemical composition and the DNA protective effect of the essential oils (EOs) from Lippia alba against bleomycin-induced genotoxicity. EO constituents were determined by Gas Chromatography/Mass Spectrometric (GC-MS) analysis. The major compounds encountered being citral (33% geranial and 25% neral), geraniol (7%) and trans-beta-caryophyllene (7%) for L. alba specimen COL512077, and carvone (38%), limonene (33%) and bicyclosesquiphellandrene (8%) for the other, COL512078. The genotoxicity and antigenotoxicity of EO and the compounds citral, carvone and limonene, were assayed using the SOS Chromotest in Escherichia coli. The EOs were not genotoxic in the SOS chromotest, but one of the major compound (limonene) showed genotoxicity at doses between 97 and 1549 mM. Both EOs protected bacterial cells against bleomycin-induced genotoxicity. Antigenotoxicity in the two L. alba chemotypes was related to the major compounds, citral and carvone, respectively. The results were discussed in relation to the chemopreventive potential of L. alba EOs and its major compounds.
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页码：479 / 488
页数：10
相关论文
共 53 条
[1]  
Abad MJ, 1997, PHYTOTHER RES, V11, P198, DOI 10.1002/(SICI)1099-1573(199705)11:3<198::AID-PTR78>3.0.CO
[2]  
2-L
[3]   Antiviral evaluation of plants from Brazilian Atlantic Tropical Forest [J].
Andrighetti-Fröhner, CR ;
Sincero, TCM ;
da Silva, AC ;
Savi, LA ;
Gaido, CM ;
Bettega, JMR ;
Mancini, M ;
de Almeida, MTR ;
Barbosa, RA ;
Farias, MR ;
Barardi, CRM ;
Simoes, CMO .
FITOTERAPIA, 2005, 76 (3-4) :374-378
[4]   Status of terpenes as skin penetration enhancers [J].
Aqil, Mohammed ;
Ahad, Abdul ;
Sultana, Vasmin ;
Ali, Asgar .
DRUG DISCOVERY TODAY, 2007, 12 (23-24) :1061-1067
[5]  
Ara N, 2009, Pak J Biol Sci, V12, P87, DOI 10.3923/pjbs.2009.87.90
[6]   Inhibitory activity of limonene against Leishmania parasites in vitro and in vivo [J].
Arruda, Denise C. ;
Miguel, Danilo C. ;
Yokoyama-Yasunaka, Jenicer K. U. ;
Katzin, Alejandro M. ;
Uliana, Silvia R. B. .
BIOMEDICINE & PHARMACOTHERAPY, 2009, 63 (09) :643-649
[7]   Essential oils: their antibacterial properties and potential applications in foods - a review [J].
Burt, S .
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY, 2004, 94 (03) :223-253
[8]   Chemical composition of the Lippia origanoides essential oils and their antigenotoxicity against bleomycin-induced DNA damage [J].
Carolina Vicuna, Gloria ;
Stashenko, Elena E. ;
Luis Fuentes, Jorge .
FITOTERAPIA, 2010, 81 (05) :343-349
[9]   Citral and carvone chemotypes from the essential oils of Colombian Lippia alba (Mill.) NE Brown: composition, cytotoxicity and antifungal activity [J].
Cecilia Mesa-Arango, Ana ;
Montiel-Ramos, Jehidys ;
Zapata, Bibiana ;
Duran, Camilo ;
Betancur-Galvis, Liliana ;
Stashenko, Elena .
MEMORIAS DO INSTITUTO OSWALDO CRUZ, 2009, 104 (06) :878-884
[10]   Nucleic acid recognition by metal complexes of bleomycin [J].
Claussen, CA ;
Long, EC .
CHEMICAL REVIEWS, 1999, 99 (09) :2797-2816
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