Synthesis and Fungicidal Activity of 3-Acetyl-4-phenyl-1-oxaspiro[4,5]dec-3-en-2-one Derivatives

被引：5

作者：

Guan, Aiying ^{[1
]}

Zhao, Yu ^{[1
]}

Wang, Weiwei ^{[1
]}

Liu, Xinlei ^{[1
]}

Wang, Mingan ^{[1
]}

机构：

[1] China Agr Univ, Coll Sci, Dept Appl Chem, Beijing 100193, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 38卷 / 10期

基金：

中国国家自然科学基金;

关键词：

diversity-orientied synthesis; 3-acetyl-4-phenyl-1-oxaspiro[4,5]dec-3-en-2-one; fungicidal activity; phytopathagen; PYRIMIDINAMINE DERIVATIVES; BIOLOGICAL-ACTIVITY; DIVERSITY SYNTHESIS; DISCOVERY; DESIGN; ETHER;

D O I：

10.6023/cjoc201804024

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The diversity-orientied synthesis strategy was utilized to diversely derive from the carbonyl of 3-acetyl-4-phenyl-1-oxaspiro[4,5]dec-3-en-2-one, a series of novel 3-acetyl-4-phenyl-1-oxaspiro[4,5]dec-3-en-2-one derivatives were synthesized. The preliminary in vivo and in vitro bioassay results showed that some compounds exhibited excellent fungicidal activity against phytopathagens, such as 3-allyloxyethyl-4-phenyl-1-oxaspiro[4,5]dec-3-en-2-one (7) had 100% control rates against Pseudoperonospora cubensis and Puccinia polysora at the concentration of 400 mu g/mL.

引用

页码：2767 / 2774

页数：8

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