Most antidepressant drugs are safe for patients with epilepsy at therapeutic doses: A review of the evidence

被引：87

作者：

Kanner, Andres M. ^{[1
]}

机构：

[1] Univ Miami, Miller Sch Med, Dept Neurol, 1120 NW,14th St,Room 1324, Miami, FL 33136 USA

来源：

EPILEPSY & BEHAVIOR | 2016年 / 61卷

关键词：

Selective serotonin reuptake inhibitors; Serotonin-norepinephrine reuptake inhibitors; Focal epilepsy; Clomipramine; Bupropion; Animal models of epilepsy; 5-HT1A RECEPTOR-BINDING; SEROTONIN-REUPTAKE INHIBITORS; EXTRACELLULAR SEROTONIN; PHARMACODYNAMIC MARKERS; PSYCHIATRIC COMORBIDITY; HIPPOCAMPAL DOPAMINE; ANTIEPILEPTIC DRUGS; 5-HYDROXYTRYPTAMINE; SEIZURES; CARBAMAZEPINE;

D O I：

10.1016/j.yebeh.2016.03.022

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

For a long time, there has been a misconception that all antidepressant drugs have proconvulsant effects. Yet, antidepressants of the selective serotonin reuptake inhibitor (SSRI) and serotonin-norepinephrine reuptake inhibitor (SNRI) families have been not only shown to be safe when used in patients with epilepsy (PWE) but have been found to display antiepileptic properties in animal models of epilepsy. In humans randomized to SSRIs vs. a placebo for the treatment of primary major depressive episodes, the incidence of epileptic seizures was significantly lower among those treated with the antidepressants. On the other hand, SSRIs and SNRIs can display proconvulsant properties at toxic doses. This article reviews the preclinical and clinical data of antiepileptic and proconvulsant properties of these drugs and addresses special considerations to take when prescribing them for PWE. (C) 2016 Published by Elsevier Inc.

引用

页码：282 / 286

页数：5

共 59 条

[1] Lamotrigine, carbamazepine and phenytoin differentially alter extracellular levels of 5-hydroxytryptamine, dopamine and amino acids [J].

Ahmad, S ;

Fowler, LJ ;

Whitton, PS .

EPILEPSY RESEARCH, 2005, 63 (2-3) :141-149

[2] Seizure incidence in psychopharmacological clinical trials: An analysis of food and drug administration (FDA) summary basis of approval reports [J].

Alper, Kenneth ;

Schwartz, Kelly A. ;

Kolts, Russell L. ;

Khan, Arif .

BIOLOGICAL PSYCHIATRY, 2007, 62 (04) :345-354

[3] Serotonin and epilepsy [J].

Bagdy, Gyorgy ;

Kecskemeti, Valeria ;

Riba, Pal ;

Jakus, Rita .

JOURNAL OF NEUROCHEMISTRY, 2007, 100 (04) :857-873

[4]

Barry J, 2008, EPILEPSY BEHAV S1, pS1

[5] 5-HYDROXYTRYPTAMINE HYPERPOLARIZES-CA3 HIPPOCAMPAL PYRAMIDAL CELLS THROUGH AN INCREASE IN POTASSIUM CONDUCTANCE [J].

BECK, SG ;

CHOI, KC .

NEUROSCIENCE LETTERS, 1991, 133 (01) :93-96

[6] MOOD CHANGE PRECEDING EPILEPTIC SEIZURES [J].

BLANCHET, P ;

FROMMER, GP .

JOURNAL OF NERVOUS AND MENTAL DISEASE, 1986, 174 (08) :471-476

[7] Hippocampal dopamine and serotonin elevations as pharmacodynamic markers for the anticonvulsant efficacy of oxcarbazepine and 10,11-dihydro-10-hydroxycarbamazepine [J].

Clinckers, R ;

Smolders, I ;

Meurs, A ;

Ebinger, G ;

Michotte, Y .

NEUROSCIENCE LETTERS, 2005, 390 (01) :48-53

[8] Quantitative in vivo microdialysis study on the influence of multidrug transporters on the blood-brain barrier passage of oxcarbazepine: Concomitant use of hippocampal monoamines as pharmacodynamic markers for the anticonvulsant activity [J].

Clinckers, R ;

Smolders, I ;

Meurs, A ;

Ebinger, G ;

Michotte, Y .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2005, 314 (02) :725-731

[9] Anticonvulsant action of hippocampal dopamine and serotonin is independently mediated by D2 and 5-HT1A receptors [J].

Clinckers, R ;

Smolders, I ;

Meurs, A ;

Ebinger, G ;

Michotte, Y .

JOURNAL OF NEUROCHEMISTRY, 2004, 89 (04) :834-843

[10] Anticonvulsant doses of carbamazepine increase hippocampal extracellular serotonin in genetically epilepsy-prone rats: Dose response relationships [J].

Dailey, JW ;

Reith, MEA ;

Yan, QS ;

Li, MY ;

Jobe, PC .

NEUROSCIENCE LETTERS, 1997, 227 (01) :13-16

← 1 2 3 4 5 6 →