Prognostic role of cyclooxygenase-2 expression in esophageal carcinoma

被引：21
作者：
Heeren, P
Plukker, J
van Dullemen, H
Nap, R
Hollema, H
机构：
[1] Univ Groningen Hosp, Dept Surg Oncol, NL-9700 RB Groningen, Netherlands
[2] Univ Groningen Hosp, Dept Gastroenterol, NL-9700 RB Groningen, Netherlands
[3] Univ Groningen Hosp, Dept Pathol, NL-9700 RB Groningen, Netherlands
来源：
CANCER LETTERS | 2005年 / 225卷 / 02期
关键词：
esophageal cancer; COX-2; expression; survival;
D O I：
10.1016/j.canlet.2004.11.046
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cyclooxygenase-2 (COX-2) is involved in esophageal carcinogenesis, but its clinical significance is not clarified yet. The association of several clinicopathological parameters with the immunohistochemical expression of COX-2 was analyzed in paraffin-embedded esophageal cancer specimens. In adenocarcinomas, COX-2 upregulation showed to be a late event and in a multivariate analysis it was associated independently with a reduced survival after surgery compared with low COX-2 expressed tumors (P=0.02). Although, the expression was extensively high in well-differentiated parts of squamous cell carcinoma, it was not related with a poor outcome. This study supports further investigation of selective COX-2 inhibitors in these tumors. (c) 2004 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：283 / 289
页数：7
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