A 20 is a regulator of necroptosis

被引：17

作者：

Gurung, Prajwal ^{[1
]}

Man, Si Ming ^{[1
]}

Kanneganti, Thirumala-Devi ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Dept Immunol, Memphis, TN 38105 USA

来源：

NATURE IMMUNOLOGY | 2015年 / 16卷 / 06期

关键词：

NF-KAPPA-B; A20; UBIQUITINATION; KINASE;

D O I：

10.1038/ni.3174

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The anti-inflammatory molecule A20 inhibits necroptotic cell death by inhibiting ubiquitination of the kinase RIPK3 at the Lys5 residue and preventing excessive formation of the RIPK1-RIPK3 necroptotic complex.

引用

页码：596 / 597

页数：2

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