Product selectivity control induced by using liquid-liquid parallel laminar flow in a microreactor

被引：32

作者：

Amemiya, Fumihiro ^{[2
]}

Matsumoto, Hideyuki ^{[3
]}

Fuse, Keishi ^{[2
]}

Kashiwagi, Tsuneo ^{[2
]}

Kuroda, Chiaki ^{[3
]}

Fuchigami, Toshio ^{[2
]}

Atobe, Mahito ^{[1
,2
]}

机构：

[1] Yokohama Natl Univ, Dept Environm & Syst Sci, Hodogaya Ku, Yokohama, Kanagawa 2408501, Japan

[2] Tokyo Inst Technol, Dept Elect Chem, Midori Ku, Yokohama, Kanagawa 2268502, Japan

[3] Tokyo Inst Technol, Dept Chem Engn, Meguro Ku, Tokyo 1528550, Japan

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2011年 / 9卷 / 11期

关键词：

ELECTROORGANIC PROCESSES; DIFFUSION-COEFFICIENTS; ELECTROCATALYTIC ACTIVITY; CARBONYL-COMPOUNDS; ORGANIC HALIDES; MICRO REACTORS; REDUCTION; ELECTROREDUCTION; ALLYLATION; BENZALDEHYDES;

D O I：

10.1039/c1ob05174a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Product selectivity control based on a liquid-liquid parallel laminar flow has been successfully demonstrated by using a microreactor. Our electrochemical microreactor system enables regioselective cross-coupling reaction of aldehyde with allylic chloride via chemoselective cathodic reduction of substrate by the combined use of suitable flow mode and corresponding cathode material. The formation of liquid-liquid parallel laminar flow in the microreactor was supported by the estimation of benzaldehyde diffusion coefficient and computational fluid dynamics simulation. The diffusion coefficient for benzaldehyde in Bu4NClO4-HMPA medium was determined to be 1.32 x 10(-7) cm(2) s(-1) by electrochemical measurements, and the flow simulation using this value revealed the formation of clear concentration gradient of benzaldehyde in the microreactor channel over a specific channel length. In addition, the necessity of the liquid-liquid parallel laminar flow was confirmed by flow mode experiments.

引用

页码：4256 / 4265

页数：10

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