The Microenvironment in Myeloproliferative Neoplasms

被引：16

作者：

Ramanathan, Gajalakshmi ^{[1
]}

Fleischman, Angela G. ^{[1
,2
]}

机构：

[1] Univ Calif Irvine, Dept Med, Div Hematol Oncol, 839 Hlth Sci Rd,Sprague Hall B100, Irvine, CA 92617 USA

[2] Univ Calif Irvine, Irvine Chao Family Comprehens Canc Ctr, Dept Biol Chem, 839 Hlth Sci Rd,Sprague Hall 126, Irvine, CA 92617 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2021年 / 35卷 / 02期

基金：

美国国家卫生研究院;

关键词：

Inflammation; Microenvironment; Cytokines; Myeloproliferative neoplasm; Prognosis; Myeloid cells; MESENCHYMAL STROMAL CELLS; TYROSINE KINASE JAK2; ESSENTIAL THROMBOCYTHEMIA; POLYCYTHEMIA-VERA; TNF-ALPHA; MUTATIONS; ACTIVATION; THROMBOSIS; DISORDERS; MYELOFIBROSIS;

D O I：

10.1016/j.hoc.2020.11.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chronic inflammation is a hallmark of myeloproliferative neoplasms (MPNs), with elevated levels of proinflammatory cytokines being commonly found in all 3 subtypes. Systemic inflammation is responsible for the constitutional symptoms, thrombosis risk, premature atherosclerosis, and disease evolution in MPN. Although the neoplastic clone and their differentiated progeny drive the inflammatory process, they also induce ancillary cytokine secretion from nonmalignant cells. Here, the authors describe the inflammatory milieu in MPN based on soluble factors and cellular mediators. They also discuss the prognostic value of cytokine measurements in patients with MPN and potential therapeutic strategies that target the cellular players in inflammation. © 2020 Elsevier Inc.

引用

页码：205 / 216

页数：12