Ruthenium-catalyzed hydrogenation of aromatic ketones using chiral diamine and monodentate achiral phosphine ligands

被引：7
|
作者：
Wang, Mengna [1 ]
Zhang, Ling [1 ]
Sun, Hao [1 ]
Chen, Qian [1 ]
Jiang, Jian [1 ]
Li, Linlin [1 ]
Zhang, Lin [1 ]
Li, Li [1 ]
Li, Chun [1 ]
机构：
[1] Guizhou Med Univ, Sch Pharmaceut Sci, Guiyang 550004, Peoples R China
来源：
CATALYSIS COMMUNICATIONS | 2021年 / 154卷
基金：
中国国家自然科学基金;
关键词：
Chiral diamines; Achiral phosphine; Ruthenium; Enantioselectivity; Ketones;
D O I：
10.1016/j.catcom.2021.106303
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
The Ru-catalyzed asymmetric hydrogenation of ketones with chiral diamine and monodentate achiral phosphine has been developed. A wide range of ketones were hydrogenated to afford the corresponding chiral secondary alcohols in good to excellent enantioselectivities (up to 98.1% ee). In addition, an appropriate mechanism for the asymmetric hydrogenation was proposed and verified by NMR spectroscopy.
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页数：6
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