Self-assembled micelles based on gambogenic acid-phospholipid complex for sustained-release drug delivery

被引：11

作者：

Wang, Beilei ^{[1
]}

Cheng, Weiye ^{[1
]}

Zhang, Caiyun ^{[1
]}

Bao, Youmei ^{[2
]}

Zha, Liqiong ^{[1
]}

Qian, Jiajia ^{[1
]}

Hong, Lufeng ^{[1
]}

Chen, Weidong ^{[1
]}

机构：

[1] Anhui Univ Chinese Med, Coll Pharm, Hefei 230038, Anhui, Peoples R China

[2] Southern Med Univ, Sch Pharmaceut Sci, Guangzhou 510515, Guangdong, Peoples R China

来源：

JOURNAL OF MICROENCAPSULATION | 2019年 / 36卷 / 06期

基金：

中国国家自然科学基金;

关键词：

GNA; GNA-PLC; GNA-PLC micelles; self-assembly; in vitro release; pharmacokinetic; POLYPRENYLATED XANTHONES; INHIBITS PROLIFERATION; GARCINIA-HANBURYI; A549; CELLS; IN-VITRO; APOPTOSIS; MAPK; DISSOLUTION; STABILITY; SYSTEMS;

D O I：

10.1080/02652048.2019.1656294

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Objective: To improve the water solubility and enhance the oral bioavailability of gambogenic acid (GNA). Methods: GNA-phospholipid complex (GNA-PLC) micelles were successfully prepared by anti-solvent method. Results: The encapsulation efficiency of GNA-PLC micelles can reach 99.33 % (w/w). The average particle size of the GNA-PLC micelles was 291.23 nm which was approximate agreed with the transmission electron microscopy (TEM). In vitro release profile showed the GNA-PLC and GNA-PLC micelles have significant sustained-release of GNA compared with crude GNA. Pharmacokinetic parameters indicated that the area under concentration-time curve (AUC(0 -> t)) of GNA in cases of GNA-PLC and GNA-PLC micelles are 2.04- and 3.92-fold higher than crude GNA, respectively. Conclusions: The better water solubility and higher bioavailability of GNA in GNA-PLC micelles with significant sustained-release of GNA endow the nanoparticle with great potential in GNA delivery system.

引用

页码：566 / 575

页数：10

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