Synthesis and Self-Assembling Behaviors of Biotinylated Pluronic/Poly(lactic acid) Biocompatible Block Copolymers in Aqueous Solutions

被引：12

作者：

Li, Zi Ling ^{[1
]}

Xiong, Xiang Yuan ^{[1
]}

Li, Yu Ping ^{[1
]}

Gong, Yan Chun ^{[1
]}

Gui, Xing Xing ^{[1
]}

Ou-Yang, Xing ^{[3
]}

Lin, Hua Sheng ^{[2
]}

Zhu, Lu Juan ^{[1
]}

Xie, Ji Lei ^{[1
]}

机构：

[1] Jiangxi Sci & Technol Normal Univ, Sch Life Sci, Nanchang 330013, Peoples R China

[2] Jiangxi Sci & Technol Normal Univ, Jiangxi Key Lab Organ Chem, Nanchang 330013, Peoples R China

[3] Jiangxi Sci & Technol Normal Univ, Sch Chem & Chem Engn, Nanchang 330013, Peoples R China

来源：

JOURNAL OF APPLIED POLYMER SCIENCE | 2010年 / 115卷 / 03期

基金：

中国国家自然科学基金;

关键词：

block copolymers; self-assembly; micelles; biocompatibility; drug delivery systems; TRIBLOCK COPOLYMERS; RELEASE KINETICS; NANOPARTICLES; DELIVERY; DRUG; MICELLES; DEGRADATION; POLYMERS; BRAIN;

D O I：

10.1002/app.31125

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Four kinds of Biotinylated Pluronic/PLA block copolymers were synthesized by two-step reactions. Pluronic were firstly modified by biotin to obtain B-Pluronic-OH. Biotin-Pluronic-PLA block copolymers were then produced by ring-opening polymerization of the monomer L-lactide using Biotin-Pluronic-OH as the initiator and stannous octoate (Sn(Oct)(2)) as the catalyst. The self-assembling behaviors of Biotin-Pluronic-PLA block copolymers in aqueous solutions were examined by fluorescence measurement, dynamic light scattering (DLS), and transmission electron microscopic (TEM) techniques. The size of Biotin-F127-PLA-61, Biotin-F87-PLA, and Biotin-P85-PLA nanoparticles were determined to be 198, 229, and 257 nm, respectively, and their morphologies were found to be spherical micelles. Biotin-F127-PLA-87 produces both spherical micelles and large compound micelles with the size of 127 and 906 nm. The cytotoxicity studies using human ovarian cancer cells OVCAR-3 indicate that Biotin-Pluronic-PLA block copolymers have good biocompatibility. (C) 2009 Wiley Periodicals, Inc. J Appl Polym Sci 115:1573-1580, 2010

引用

页码：1573 / 1580

页数：8

共 26 条

[1] Stimuli responsive polymers for biomedical applications
Alarcón, CDH
Pennadam, S
Alexander, C
[J]. CHEMICAL SOCIETY REVIEWS, 2005, 34 (03) : 276 - 285
[2] Solid lipid nanoparticles for targeted brain drug delivery
Blasi, Paolo
Glovagnoli, Stefano
Schoubben, Aurelie
Ricci, Maurizio
Rossi, Carlo
[J]. ADVANCED DRUG DELIVERY REVIEWS, 2007, 59 (06) : 454 - 477
[3] Cannizzaro SM, 1998, BIOTECHNOL BIOENG, V58, P529, DOI 10.1002/(SICI)1097-0290(19980605)58:5<529::AID-BIT9>3.0.CO
[4] 2-F
[5] Stimuli-reponsive polymers and their bioconjugates
Gil, ES
Hudson, SM
[J]. PROGRESS IN POLYMER SCIENCE, 2004, 29 (12) : 1173 - 1222
[6] GREEN NM, 1965, BIOCHEM J, V94, P23
[7] Surface-engineered nanoparticles for multiple ligand coupling
Gref, R
Couvreur, P
Barratt, G
Mysiakine, E
[J]. BIOMATERIALS, 2003, 24 (24) : 4529 - 4537
[8] Synthesis and characterization of biodegradable amphiphilic triblock copolymers containing L-glutamic acid units
Guan, HL
Xie, ZG
Zhang, PB
Deng, C
Chen, XS
Jing, XB
[J]. BIOMACROMOLECULES, 2005, 6 (04) : 1954 - 1960
[9] ABA-triblock copolymers from biodegradable polyester A-blocks and hydrophilic poly(ethylene oxide) B-blocks as a candidate for in situ forming hydrogel delivery systems for proteins
Kissel, T
Li, YX
Unger, F
[J]. ADVANCED DRUG DELIVERY REVIEWS, 2002, 54 (01) : 99 - 134
[10] Incorporation and release behavior of hydrophobic drug in functionalized poly(D,L-lactide)-block-poly(ethylene oxide) micelles
Lee, JY
Cho, EC
Cho, K
[J]. JOURNAL OF CONTROLLED RELEASE, 2004, 94 (2-3) : 323 - 335

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